分类号R341单位代码:10160学号:0170664硕士学位论文题目:rUsher综合征11型家系PCDH15基因的突变分析与产前诊断AnalysisofPCDH15genemutationandprenataldiagnosisinapedigreeaffectedwithUsherSyndrometype1研究生:李亚娟导师:郝冬梅学科专业:妇产科学论文课题起止时间
Ivanchenko, M.V., Hathaway, D.M., Klein, A.J. et al. Mini-PCDH15 gene therapy rescues hearing in a mouse model of Usher syndrome type 1F. Nat Commun 14, 2400 (2023). https://doi.org/10.1038/s41467-023-38038-y
Protocadherin Related 15 (PCDH15) gene is a member of the cadherin superfamily that encode membrane proteins involved in cell-cell adhesion. In this study, we aimed to investigate the prognostic value of PCDH15 expression in Low-Grade Gliomas (LGG) and Glioblastoma Multiforme (GBM).Methods: We...
1. Splice variants: Alternative splicing may create different sized proteins fromthe samegene. 2. Relative charge: The composition of amino acids may affects the charge of the protein. 3. Post-translational modification: Phosphorylation, glycosylation, methylation etc. ...
pECMV-Pcdh15-m-FLAGAddgene NGS results GTTTCGGTGATGACGGTGAAAACCTCTGACACATGCAGCTCCCGGAGACGGTCACAGCTTGTCTGTAAGC GGATGCCGGGAGCAGACAAGCCCGTCAGGGCGCGTCAGCGGGTGTTGGCGGGTGTCGGGGCTGGCTTAAC TATGCGGCATCAGAGCAGATTGTACTGAGAGTGCACCATATGCGGTGTGAAATACCGCACAGATGCGTAA ...
retina, ciliary body, retinal pigmented epithelium (RPE)-choroid, iris, human brain (Clontech), and human liver (Clontech), along with RNA size standards (Life Technologies), were electrophoresed on an agarose-formaldehyde denaturing gel and were transferred to GeneScreen Plus membrane (Dupont-...
1.Splice variants: Alternative splicing may create different sized proteins from the same gene. 2. Relative charge: The composition of amino acids may affects the charge of the protein. 3. Post-translational modification: Phosphorylation, glycosylation, methylation etc. 4. Post-translation cleavage: ...
These mice carry loxP sites flanking target exons of Pcdh15 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Pcdh15 gene. *使用本品系发表的文献需注明: Pcdh15-Flox mice (Cat. NO. TBD) were purchased fro...
METHODS: A PCDH15 MLPA (multiplex ligation-dependent probe amplification) commercial kit was used, combined with a customized oligonucleotide array-based CGH analysis (aCGH), containing almost 20,000 probes tiling the nonrepetitive sequence of the PCDH15 gene. RESULTS: Two large intragenic ...
兔TGF-β诱导早期应答基因1(TIEG1)ELISA试剂盒 Rabbit TIEG1 (TGF Beta Inducible Early Response Gene 1) ELISA Kit 兔G蛋白偶联受体家族C5组成员(GPRC5A)ELISA试剂盒 Rabbit GPRC5A (G Protein Coupled Receptor, Family C, Group 5, Member A) ELISA Kit 兔C-反应蛋白(CRP)ELISA试剂盒 Rabbit CRP (C-...