BACKGROUNDPSP94 (prostate secretory protein of 94 aa; also called PIP), one of the predominant proteins secreted into the seminal fluid, was proposed as an independent diagnostic/prognostic marker for prostate cancers. It was also shown to inhibit rat prostate cancer growth. In this study, ...
其中TRPC(TRPC1-7)通道亚家族和果蝇中TRP通道同源度最高。而TRPC3/6/7亚类也像果蝇TRP通道一样,可以被受体偶联的磷脂酶C(PLC)水解PIP2 所生成的DAG所激活,因此被称为受体激活的TRPC通道亚类。这些受体激活的TRPC通道开放后会导致膜电位的去极化和钙离子的内流。它们广泛地分布于人体组织,并参与了多种生理过程...
其中TRPC(TRPC1-7)通道亚家族和果蝇中TRP通道同源度最高。而TRPC3/6/7亚类也像果蝇TRP通道一样,可以被受体偶联的磷脂酶C(PLC)水解PIP2 所生成的DAG所激活,因此被称为受体激活的TRPC通道亚类。这些受体激活的TRPC通道开放后会导致膜电位的去极化和钙离子的内流。它们广泛的分布于人体组织,并参与了多种生理过程...
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? 2024 Elsevier LtdTransient receptor potential canonical 3 (TRPC3) is a calcium-permeable, non-selective cation channel known to be regulated by components of the phospholipase C (PLC)-mediated signaling pathway, such as Ca2+, diacylglycerol (DAG) and phosphatidylinositol 4,5-biphosphate (PI(4...
c(PLC)13和Y来继发激活TRP通道。PLC水解4,5.二磷酸磷脂肌醇(PIP2),生 成肌醇三磷酸(IP3)和甘油二酯(DAG),IP3水平的升高,使得细胞内钙库释放, 细胞内钙库清空可开放TRPC通道[22],此外DAG也可直接激活TRPC通道[23】。 几乎所有的TRPC亚型通道都可被该通路激活。故TRPC3可以被DAG或其类 ...
变构 D. 变性 6 从内质网释放的第二信使是( ) A. cAMP B. cGMP C. DG D. Ca2+ 7 G蛋白偶联受体与下列哪条信号通路无关( ) A. 酪氨酸蛋白激酶系统 B.Ca++-CaM通路 C. DG-PKC通路 D. cAMP-PKA通路 8 下列哪种酶可水解PIP2(磷脂酰肌醇二磷酸)生成DAG和IP3( ) A. 磷脂酶A B.磷脂酶B C....
In endothelial cells, it is generally considered that the binding of bradykinin to its receptors – B1 and/or B2 receptors, which are G-protein coupled receptors, activates phospholipase C to catalyze the hydroly- sis of PIP2 to yield IP3 and DAG. A biphasic elevation of endothelial [Ca2+...
Brain acid soluble protein 1 (BASP1) promotes WT1's transcriptional repression activity through PIP2-dependent recruitment of histone deacetylase [9,35]. BASP1 expression is evident in developing nephron structures in the embryonic kidney and in adult podocytes. In a conditionally-immortalised human ...
PIP2 ER SR IP3 ET.1 SAH PD AD SCAl4 第三军医大学硕士学位论文 英文缩写一览表 Malformedneurons Dysmorphic neurons Giantcells Tuberoussclerosis complex 中文全名 异构神经元 异形神经元 巨形细胞 结节性硬化 focalcortical dysplasia 局灶性皮质发育不良 ...