Our PBMC-mediated ADCC assay services provide a reliable and efficient route to evaluate the cytotoxic potential of therapeutic antibodies, fostering the development of promising immunotherapies. For more information or to discuss your specific requirements, please contact us today. ...
Three considerations affected our new assay design: 1) normal B cells within PBMCs introduce 'cold target' competition of radiolabeled tumor B cells if anti-B cell antibodies are present in the ADCC assays; 2) type 1 antibodies to CD20 B cell epitopes are internalized and cleared from the ...
Based on its lack of ADCC activity47 and the generally poor FcR binding ability of IgG4 in the presence of a huge access of competing high-affinity binders present in culture medium on the one side, and the presence of FcR-positive B cells and monocytes within fresh PBMC preparations on ...
Comparison of neutralizing antibody responses to CM235 in the IMC/PBMC assay and ADCC responses to CM235 in the ADCC-Luciferase assay.Agricola JoachimCharlotta NilssonSaid AboudMuhammad BakariEligius F. LyamuyaMerlin L. RobbMary A. Marovich