CAS1222490-34-7 PBD-dimer PBD二聚体 ADC抗体简介 接下来由r瑞 x禧小编来为大家介绍——ADC由“抗体”、“接头”和“效应分子”三个主要组件构成。效应分子(payload)原指细胞毒素加上接头部分,现经常和细胞*素混用。其中接头通常还包括和抗体偶联的隔离区(spacer) .化学或酶裂解区、释放效应分子的消除区等。
产品名称:PBD二聚体PBD-dimer1222490-34-7 供应商:西安齐岳生物科技有限公司 纯度:95%+ 存储条件:-20°C,避光,避湿 用途:科研 状态:固体/粉末/溶液 产地:西安 保存:冷藏 ADC由“抗体”、“接头”和“效应分子”三个主要组件构成。效应分子(payload)原指细胞毒素加上接头部分,现经常和细胞*素混用。其中接头...
10. Hartley JA, Flynn MJ, Bingham JP, et al. Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine. Sci R...
ADCs delivering PBD dimer payloads represent a novel mode of action in the ADC area. An important feature of the highly cytotoxic DNA interstrand cross-links produced by the PBD dimers is their persistence in cells. This contributes to their potency and also to their ability to affect slowly ...
[PBD dimer-2]化源网提供PBD dimer-2CAS号145325-57-1,PBD dimer-2MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询PBD dimer-2上化源网,专业又轻松。
light,storedundernitrogen)BIOLOGICALACTIVITY⽣物活性PBDdimer-2(compound2c)⼀种C8连接的吡咯苯⼆氮卓⼆聚体。PBDdimer-2可以跨越⼀个额外的碱基对,并交联5'-Pu-GA(T/A)TC-Py序列。PBDdimer-2可以作为抗体-药物偶联物(ADC)的有效载荷,可⽤于癌症的研究。REFERENCES[1].SmellieM,etal.Sequence-select...
PBD dimer SG3199 is the released warhead component of the antibody-drug conjugate (ADC) payload tesirine (SG3249), currently being evaluated in several ADC clinical trials. SG3199 was potently cytotoxic against a panel of human solid tumour and haematological cancer cell lines with a mean GIof ...
This mechanism of action suggests that PARP inhibitors such as Veliparib may enhance the activity of PBD-dimer ADCs. The combination of ABBV-176 and the PARP inhibitor Veliparib demonstrated enhanced activity in the BRCA1 deficient triple negative breast model CTG-0670 as well as the liver CDX ...
Loncastuximab tesirine-lpyl (formerly ADCT-402) is an antibody-drug conjugate (ADC) comprising a humanised anti-CD19 monoclonal antibody conjugated to the pyrrolobenzodiazepine (PBD) dimer-based payload tesirine. Once bound to CD19 on th... N Sachini,A Jabeen,PVV Berkel,... - 《Blood》 ...
Dimethyl-SGD-1882(Synonyms: Dimethyl-PBD dimer) Dimethyl-SGD-1882 (Dimethyl-PBD dimer) 是一种高效的 DNA 烷化剂 (DNA alkylator),可作用做抗体偶联药物 (ADC) 的毒素部分。PBD Dimer 是一种 DNA 烷化剂,能抑制 DNA 复制。 Dimethyl-SGD-1882Chemical Structure ...