PB1-F2-induced mitophagy was critical for the MAVS (mitochondrial antiviral signaling protein) degradation and led to its suppression of the type I IFN production. Importantly, the C-terminal LIR motif of PB1-F2 protein was demonstrated to be essential for its mitophagy induction and attenuated ...
PB1-F2RIG-IPB1-F2 is a nonstructural protein of influenza viruses encoded by the PB1 gene segment from a +1 open reading frame. It has been shown that PB1-F2 contributes to viral pathogenicity, although the underlying mechanisms are still unclear. Induction of type I interferon (IFN) ...
F2结合的关键区域.因此,PB1-F2扮演了自噬受体蛋白的角色同时与LC3B及TUFM domain I相互作用从而介导了线粒体自噬的发生.2)PB1-F2蛋白抑制线粒体自噬依赖的I型IFN的产生我们发现沉默掉TUFM及自噬基因ATG5(autophagy related 5)或过表达PB1-F2的LIR突变体抑制线粒体自噬过程均削弱了PB1-F2抑制I型IFN(interferon...
In contrast, exacerbation of IFN-β expression and the inflammatory response were observed in epithelial cells (23). The different functions of PB1-F2 might be linked to its disordered protein feature, capable to switch from random to α-helical or β-sheet secondary structure, depending on the...
(IL,IL-8,IFNα,IFNβ,IFNγ,MCP-1)的]mRNA相对表达水平,IL-8在感染8h后相对表达水平最高,IFNα/β在感染32h后表达水平显著上升,除MCP-1外PB1-F2断裂株和全长株细胞因子表达水平均无统计学意义.5.流感病毒反向遗传体系...
ybm-0388MIFN gamma(F2E4)γ-干扰素/γ-IFN单克隆抗体 yb-0481RIFN gamma干扰素-γ/IFN-γ抗体 yb-0480RIFN gamma干扰素-γ/IFN-γ抗体 yb-0227RIGF1R胰岛素样生长因子I受体抗体 yb-0680RIGF1R胰岛素样生长因子1受体抗体 yb-1108RIGFBP2胰岛素样生长因子结合蛋白2抗体 ...
6-Chloroguanine riboside 中文名:6-氯鸟嘌呤核苷 分子式:C10H12ClN5O4 度:95.0% 小鼠γ干扰素(IFN-γ)ELISA试剂盒 96T/48T 试剂盒 组装/原装 小鼠基质细胞衍生因子1a(SDF-1a/CXCL12)ELISAKit ELISA. 96T/48T Boldenone 846-48-0 中文名:宝丹酮 分子式:C19H26O2 小鼠基质细胞衍生因子-1a(mouse SDF-1a...
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(F,G) PB1-F2, but not empty vector (pcDNA3.1) or the Flag tag (3xFlag), inhibits chicken IFN-β promoter activity downstream of duck RIG-I CARD domains (2CARD) in DF-1 cells, by dual luciferase assay. (H) PB1-F2, but not empty vector (pcDNA3.1) or the Flag tag (3xFlag),...