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病情分析:PAX8阳性通常提示该组织来源于肾脏、甲状腺或女性生殖系统的上皮细胞。 1.PAX8是一种转录因子,在胚胎发育过程中发挥重要作用,尤其在泌尿生殖系统和甲状腺的发育中。 2.在病理学中,PAX8阳性染色常用于鉴别不同类型的癌症。对肾细胞癌、卵巢浆液性癌、甲状腺乳头状癌等具有较高的特异性。 3.PAX8检测帮助病理...
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PAX8 别名 Paired box 8 概述 核转绿因子,PAX(pair box gene)家族成员之一。表达于甲状腺、肾导管组织、副中肾管组织及相关肿瘤中,对于转移性肾细胞癌,PAX-8的敏感性优于CD10和RCC。 阳性表达主要见于肾肿瘤(肾细胞癌及肾集合管癌)、苗勒管肿瘤(80-85%)、甲状腺肿瘤;其它阳性表达肿瘤包括胸腺瘤/癌和胰腺...
PAX8是一种转录因子,在肾脏、苗勒氏管(Müllerian)来源器官、甲状腺的胚胎发育中发挥重要作用,对这类器官发生的肿瘤也有关键作用。为详尽探索该指标在人体器官及相应肿瘤中的免疫组化表达情况,美国休斯敦卫理公会医院(Methodist Hospital)Ozcan等对人体非肿瘤组织、相关原发肿瘤及转...
PAX8 (paired box 8) 该基因编码转录因子成对盒(PAX)家族的一个成员。这个基因家族的成员通常编码包含成对盒结构域、八肽和成对型同源结构域的蛋白质。这种核蛋白参与甲状腺滤泡细胞的发育和甲状腺特异性基因的表达。该基因突变与甲状腺发育不全、甲状腺滤泡癌和非典型甲状腺滤泡腺瘤有关。另外,还描述了编码不同亚型...
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