In Panel B, the box plots show medians, interquartile ranges, and total ranges at the level of the intensive care unit day, with outliers excluded for legibility. Intensive care units are ordered on the x-axis from lowest median ratio to highest median ratio Full size image In our primary...
If sample size is not established based on the PRO end point, then discuss the power of the principal PRO analyses. Explanation: In studies in which PROs are the primary outcome or end point, the target sample size will generally be based on an a priori sample size calculation for that ...
The sample size calculation is based on the following assumptions: Semi-structured interviews with a patient panel of 12 women identified that any reduction in UTI episodes even by one per year would be deemed worthwhile. Therefore, we have set the minimum clinically important difference between ...
21 Item 14 of the SPIRIT-PRO Extension indicates that if PROs are the primary outcome of a study, a priori sample size calculation should be provided for that specific end point. If PROs are a secondary outcome, the sample size should provide enough power to test the principal PRO ...
correction for multiple-hypothesis testing for the indicated pairwise comparisons.#P < 0.05 indicating both dsgNQO1 conditions are less than the corresponding dsgChr1 condition. The inset of the lower panel of (C) illustrates the potential relationships between sulforaphane (SF), the ...
Dosage Calculation:Calculating a patient's dosage depends on several factors such as the patient's weight, age, medical history, the condition being treated, and the medication being prescribed. However, as a general guideline, the dosage is calculated...
Detector configuration in the WT-PET along with the panel dimensions Full size image One concern with such a system is the issue of patient motion, which may be higher for standing patients compared to lying patients, leading to deterioration of image quality.This arises from two types of movem...
The symptom checklist was developed by a panel of epilepsy experts and included symptoms considered likely to occur frequently among patients with epilepsy (anxiety, depression, fatigue, headache, insomnia, memory problems, pain, problems concentrating, and somnolence). Patients could also document ...
Sample Size Calculation Details are in the trial protocol and statistical plan (Supplement 1 and Supplement 2).5,11 Accounting for the correlation within clusters, the trial was designed to have at least 80% power to detect a between-group difference of 12 steps per 100 patient-years (assumed...
Sample Size and Power Calculation The study was powered to detect noninferiority in RMDQ scores in the AI-CBT-CP group relative to the group receiving standard therapist-delivered telephone CBT-CP. Prior recommendations for minimally significant changes in RMDQ scores range from 2 to 8 points, and...