A foam rubber sleeve is positioned around the lower legs, ankles and heels of a bedridden patient to protect the patient's skin from bed sores. The sleeve panels are transposed to leave the heels clear of surface contact. The foam rubber sleeve is body profile-conformal. The sleeve is secured by a hook and loop fixture.LINNEMAN...
theLost in Space Achievementhas beenremoved. It becamevery hard or impossible to obtain or guess correctly. If suggested, it might bere-added laterfor the few remainingImminent Terminationcases — but undecided for now.
Over the past two decades, technological advances in membrane protein structural biology have provided insight into the molecular mechanisms that transporters use to move diverse substrates across the membrane. However, the plasticity of these proteins’ ligand binding pockets, which allows them to bind...
Without any explanation, the locals witnessed the spontaneous combustion of mattresses, beds, cars, refrigerators and even cell phones.At the time, the episodes attracted the attention of geologists, physicists and volcanologists. However, none of the professionals could provide a scientific explanation ...
the fasted state (Extended Data Table2). Body weight and body composition did not differ between the groups and visits (P > 0.05; Table1). However, liver fat content increased in the HCD group (group-by-visit interaction, estimate of −0.11, 95% CI −0.19 to −0.03,P =...
Earlier in the week we did a presentation at an event on Inflammatory Bowel Disease (IDB) which was hosted by a patient and clinician led group who want to raise the profile of the disease and what help there is available. We are asked if we could produce some information that patients ...
Mast cells have been linked to osteoporosis and bone fractures, and in a previous study we found that mice lacking a major mast cell protease, chymase, develop increased diaphyseal bone mass. These findings introduce the possibility that mast cell chymase can regulate bone formation, but the und...
Described as the “fourth most upregulated transcript” in all cancers [1], its increased abundance is linked at the clinical level to tumour resistance to chemo and radiation treatments, and its presence predicts a poor prognosis for the patient [2],[3]. Survivin expression is regulated by ...
To tolerate oxidative stress, cells enable DNA repair responses often sensitive to poly(ADP-ribose) (PAR) polymerase 1 and 2 (PARP1/2) inhibition—an intervention effective against cancers lacking BRCA1/2. Here, we demonstrate that mutating the CHD6 chro
(2015) showed that 83% of tumors have ARID1A overexpression when compared with adjacent tissues. In endometrial cancer, primary tumors expressed wild-type (WT) ARID1A but metastatic subclones from the same patient harbored deleterious mutations, suggesting that perhaps ARID1A was required in early...