Cancer cells lack a tumor microenvironment (TME) and genetic diversity, whereas PDTXs are expensive and have a time-consuming preparation protocol. Therefore, alternative research models are warranted. Patient-derived organoids (PDOs) are a promising in vitro model. They m...
Over the past decade, the emergence of patient-derived tumor organoids (PDTOs) has broadened the repertoire of preclinical models and progressively revolutionized three-dimensional cell culture in oncology. PDTO can be grown from patient tumor samples with high efficiency and faithfully recapitulates th...
Organoids (and cancer-derived organoids), are three-dimensional tissue-resembling cellular clusters derived from tissue or tumor specific stem cells that mimic the in vivo (tumor) characteristics, as well as (tumor) cell heterogeneity. Cancer organoids may further enhance the in vitro and in ...
Among these patients, three were further pursued to have the organoids derived from their tumor tissues tested for the sensitivity to different therapeutic drugs in parallel to their clinical care. Our results showed that the therapeutic effects observed by the organoid models were consistent to the...
patient-derived cancer organoids, also known as tumouroids, recapitulate in vivo tumour characteristics including tumour architecture. Tumouroids have been used for general disease modelling and genetic instability studies in pan-cancer research. However, a limited number of studies have thus far been ...
Patient-derived tumor organoids: a new avenue for preclinical research and precision medicine in oncology Over the past decade, the emergence of patient-derived tumor organoids (PDTOs) has broadened the repertoire of preclinical models and progressively revolutionized three-dimensional cell culture in ...
In a first-of-its-kind trial, researchers used tiny, simplified organs grown from patients' cancer cells—so-called patient-derived organoids (PDOs)—to co... Abbasi,Jennifer - 《Jama》 被引量: 3发表: 2018年 High-throughput drug screening (HTDS) of patient-derived tumor organoids (PTDO...
Patient-derived tumor cell organoid culture mimic parental tumors From a histopathological perspective, PDX models largely retain parent tumor architecture, as described above. Further, at the cellular level, both inter-tumoral and intra-tumoral heterogeneity, as well as the phenotypic and molecular char...
Discovering Tumor Microenvironment Dynamics in HPV-Associated Cancers: Using Organoid-Based Models to Develop Therapeutics Babak Arjmand Ghazal Najafi Bagher Larijani Regenerative Engineering and Translational Medicine(2025) Establishing patient-derived tumor organoids of bone metastasis from lung adenocarcinoma ...
Precision modeling of gall bladder cancer patients in mice based on orthotopic implantation of organoid-derived tumor buds Shingo Kato Kentaro Fushimi Atsushi Nakajima ArticleOpen Access17 Apr 2021Oncogenesis Molecular biological analysis of 5-FU-resistant gastric cancer organoids; KHDRBS3 contributes to...