After reperfusion of cerebral blood flow, oxidative stress increases mitochondrial damage further [12, 13] and generates excessive ROS [14]. The ROS accumulation-mediated oxidative stress and lipid peroxidation are the key driving forces triggering cellular ferroptosis [15, 16]. In addition, over...
2021). Fifteen mice were assigned to the sham surgery group, where a nylon thread was only inserted into the external carotid artery without disrupting blood flow, following the same protocol as the surgical group. The mortality rate of mice during the procedure was below 10% (Figure S1). ...
2021). Fifteen mice were assigned to the sham surgery group, where a nylon thread was only inserted into the external carotid artery without disrupting blood flow, following the same protocol as the surgical group. The mortality rate of mice during the procedure was below 10% (Figure S1). ...
Regarding patient demographics and global health status, we collected patients’ age, sex, body mass index, current tobacco use, and data related to the following set of comorbidities: high blood pressure (HBP), chronic obstructive pulmonary disease (COPD), diabetes, renal failure, and atrial fibr...
The whole process of collecting human specimens has been approved by the Medical Ethics Committee of Nanjing Medical University in advance. In this experiment, primary colorectal cancer and corresponding intestinal tissue, liver metastatic cancer tissue and corresponding normal liver tissue, blood before ...
Blood 118, 5189–5200 (2011). Article CAS PubMed PubMed Central Google Scholar Stossel, C. et al. Spectrum of response to platinum and PARP inhibitors in germline BRCA-associated pancreatic cancer in the clinical and preclinical setting. Cancer Discov. 13, 1826–1843 (2023). Article CAS ...
PBS was added to the lower cells of BALF for resuspension, and the cells were classified and calculated using an automated cell counter (Mindray, China). Mouse blood was obtained from the eyeballs, set aside for 2 h at room temperature, and then centrifuged (4000 rpm, 30 min, 4 °C)...
Phosphoglucomutase 1 (PGM1) is known for its involvement in cancer pathogenesis. However, its biological role in colorectal cancer (CRC) has remained unknown. Here, we studied the functions and mechanisms of PGM1 in CRC. We verified PGM-1 as a differenti
TheCYP24A1gene, which is located on chromosome 20q13.2, codes for the vitamin D inactivating enzyme 24-hydroxlase. This enzyme controls the levels of vitamin D in blood serum by breaking down the active form to biliary excretory products and by reducing intestinal absorption of calcium and phos...
A previous study reported that the administration of 1.5 g GW to patients with atopic dermatitis for 10 weeks resulted in an increase in ceramide levels and improved stratum corneum hydration without any abnormalities in anthropometric measurements or blood analysis [27]. This indicates that the ...