It is estimated that two-thirds of all proteins in higher organisms are composed of multiple domains, many of them containing discontinuous folds. However, to date, most in vitro protein folding studies have focused on small, single-domain proteins. As a model system for a two-domain discontinu...
After examining mouse, rat and human breast cancer cells, they found that ZBP1 silencing occurs when a methyl group attaches to ZBP1's promoter region (the segment of a gene where gene expression is initiated). The attachment of methyl group prevents the promoter from binding to a protein ca...
As a DAMP, mtDNA not only contributes to anti-viral resistance, but also causes pathogenic inflammation in many disease contexts. Cells experiencing mtDNA stress caused by depletion of the mtDNA-packaging protein, transcription factor A, mitochondrial (TFAM) or during herpes simplex virus-1 infection...
Proteins are important building blocks in our cells and each cell contains millions of different protein molecules. They are involved in everything from structural to regulatory aspects in the cell. Proteins are constructed as linear molecules but they only become functional once they are folded into...
A LeviEmbo JournalPossenti R, Eldridge JD, Paterson BM, Grasso A, Levi A (1989): A protein induced by NGF in PC12 cells is stored in secretory vesicles and released through the regulated pathway. EMBO J 8:2217-2223.Possenti, R., Eldridge, J. D., Paterson, B. M., Grasso, A., ...
a phase II clinical assay indicated that recombinant human FGF18 protein effectively enhances the proliferation of chondrocytes and the production of extracellular matrix, suggesting it has good potential to treat joint diseases9. Furthermore, FGF18 participates in clear cell renal cell carcinoma prolifer...
Thus, it is plausible that inhibiting AXL-mediated EMT is critical for the management of osteosarcoma metastasis. Fibroblast activation protein alpha (FAPα), a type II transmembrane protein that belongs to the prolyl dipeptidyl aminopeptidase family, functions as a dipeptidyl peptidase that cleaves ...
Plant genome contains entire genetic information of a species, recording its evolutionary history and direction. Comprehensive understanding of plant genome evolution is important in revealing the relationships and evolutionary processes among plant species. Moreover, it reveals the genetic foundations that ...
Fas gene encodes for transmembrane protein I (319 amino acid residues) while FasL encodes for transmembrane protein II (281 amino acid residues) [7], [8]. In addition to the proappoptotic property of Fas/FasL signaling pathway, several evidences demonstrated that this pathway can also activate...
(Beyotime Biotechnology, PC0020, Shanghai, China) was used for determining the protein concentrations. For extraction of protein in bone, the bone marrow was flushed out, and the bone tissue were grinded with liquid nitrogen before the addition of RIPA. Equal amounts of proteins were subjected ...