Many rodent models are available for preclinical diabetes research making it a challenge for researchers to choose the most appropriate one for their experimental question. To aid in this, models have classically been categorized according to which type of diabetes they represent, and further into whe...
Diabetes and stroke: part one–risk factors and pathophysiology. Curr Cardiol Rep. 2006; 8 (1):23–28. doi: 10.1007/s11886-006-0006-1. [ Cross Ref ]Baliga BS,Weinberger J. Diabetes and stroke: part one--risk factors and pathophysiology.[J].Current cardiology reports 2006,1(1)....
Previous studies reported reduced renal SIRT1 protein expression, especially in a model of diabetes, and these studies have examined the effect of proximal tubular SIRT1 and epigenetic regulation of claudin-1 in podocytes24,26,27 on diabetic kidney disease, but this interplay is still unclear in ...
Although diabetes is now a global epidemic, China has the highest number of affected people, presenting profound public health and socioeconomic challenges. In China, rapid ecological and lifestyle shifts have dramatically altered diabetes epidemiology a
A review of pediatric research on this topic has recently been presented in detail by Hanevold [51]. In short, pediatric studies showed that SS is evident in children with obesity, diabetes (both type 1 and type 2), born prematurely and as small for gestational age (SGA), and it is ...
Valvular heart disease (VHD) is caused by either damage or defect in one of the four heart valves, aortic, mitral, tricuspid or pulmonary. Defects in these valves can be congenital or acquired. Age, gender, tobacco use, hypercholesterolemia, hypertension, and type II diabetes contribute to the...
The latter is more likely to be associated with monomicrobial infection while the former is often polymicrobial in origin including obligately anaerobic bacteria Osteomyelitis in individuals with vascular insufficiency including patients with diabetes mellitus is also frequently polymicrobial (Powlson & Coll,...
That’s a function of a couple of different things. One, the underlying comorbidities that contribute to heart failure are becoming more common. We also have emerging therapies, including those we’re going to talk about in this discussion, that have enabled us to manage patients with heart ...
Acromegaly is a rare endocrine disease caused by hypersecretion of growth hormone, most commonly arising due to a pituitary adenoma. Diabetes mellitus is a common complication of acromegaly, occurring in approximately one-third of patients. The risk of diabetes mellitus in acromegaly is driven by in...
There are many aspects to the relationships between hypertension and diabetes. These range from the question of whether elevated blood pressure is characteristic of those predisposed to develop noninsulin-dependent diabetes, as was suggested by one of the earlier epidemiologic studies of the incidence ...