Arthrofibrosis is the pathological stiffening of a joint due to an exaggerated inflammatory response. As a relatively common complication following total knee arthroplasty (TKA), this benign appearing connective tissue hyperplasia can cause significant disability among patients as the concomitant knee pain ...
Patellar tendon ruptures also can occur as a complication of total knee arthroplasty, [6] anterior cruciate ligament (ACL) reconstruction using the patellar tendon as an autograft, [7] or excision of chronic tendinosis. However, the etiology and treatment in these circumstances are beyond the ...
O-linked N-acetylglucosamine (O-GlcNAc) protein modification (O-GlcNAcylation) is a critical post-translational modification (PTM) of cytoplasmic and nuclear proteins. O-GlcNAcylation levels are regulated by the activity of two enzymes, O-GlcNAc transfer
Although no effective protocol had previously been developed for preventing HO after SCI, the authors' studies, based on the well-documented beneficial effect of nonsteroidal anti-inflammatory drugs (NSAIDs) in the prevention of HO after total hip arthroplasty, showed that the following drugs can ...
As the population of the Western world ages, the number of major surgical procedures performed in the elderly population will by necessity increase. Within virtually every surgical specialty, studies have shown that patients should not be denied surgery on the basis of chronological age alone. It ...