Due to the high global rate of total hip and knee replacement, endoprostheses represent an increasingly common source of infection, although infections of other implants such as orthopaedic internal fixation devices are also commonly seen. Stainless steel, titanium, and titanium alloys are the most ...
The AACE/ACE did not introduce the name as an actual replacement for the term obesity but instead as a means of helping the medical community focus on the pathophysiologic impact of excess weight. [16] For information on pediatric obesity, see Obesity in Children. Measurements of obesity ...
USA; 2Department of Aging and Geriatric Research, Institute on Aging, Pain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL, USA Abstract: For decades, multiple attempts to fully understand knee osteoarthritis pathophysiology and natural history have been attempted....
The Author(s) 2021, corrected publication 2022 Abstract Duchenne muscular dystrophy is a highly progressive muscle wasting disorder due to primary abnormalities in one of the largest genes in the human genome, the DMD gene, which encodes various tissue-specific isoforms of the protein dystro- ph...
The first description of fibromyalgia syndrome (FMS) is found in the nineteenth century. The term “fibrositis”, which Gowers first used in 1904, was in use until the 1970s and 1980s, when a central nervous system-related etiology was proposed [1]. In 1950 Graham described fibrositis as...
In all, a total of two net molecules of ATP and two NADH are produced per one molecule of glucose during glycolysis. As shown in Figure 1, glycolysis starts with the phosphorylation of glucose by the enzyme hexokinase, which utilizes ATP to produce glucose-6-phosphate (G-6-P), and ends...
Fractures can be severely debilitating to patients, especially those that interfere with activities of daily living and quality of life. These include injuries of the hip, including femoral head or pelvic fractures, and injuries of the knee, including distal femoral and proximal tibial fractures. Up...
treatment target. The evidences obtained by basic science suggests a pathogenic role of hyperuricemia in the development of chronic kidney disease (CKD) and cardiovascular diseases (CVD), by inducing inflammation, endothelial dysfunction, proliferation of vascular smooth muscle cells, and activation of ...