Diagnostic Strategies A severe anion gap metabolic acidosis Because the onset of acidosis may be delayed 12 to 24 hours, the presence of a normal anion gap does not rule out methanol exposure. anion gap is due primarily to the presence of formic acid, with a variable contribution from lactic ...
Increasing public awareness of potential hepatotoxins, including over-the-counter medications such as acetaminophen (ie, paracetamol) and ibuprofen, is essential. Despite an effective antidote, acetaminophen overdose remains a frequent cause of acute liver failure in children. [3] See Acute Liver Fail...
N-acetyl-l-cysteine (NAC) has long been used therapeutically for the treatment of acetaminophen (paracetamol) overdose, acting as a precursor for the substrate (l-cysteine) in the synthesis of the hepatic glutathione (GSH) depleted through drug conjugation. More recently, however, many clinical ...