To delineate clinical characteristics useful for identifying children with liver failure due to accidental paracetamol overdose. Retrospective review of medical records of all patients admitted from 1985 to 1998 with fulminant hepatic failure. Royal Alexandra Hospital for Children, a tertiary referral centre...
Since we could not exclude a toxic aetiology, and paracetamol overdose in particular, we implemented prospective syndromic surveillance to better define the clinical characteristics of these children. To investigate risk factors, we performed a case–control study. Methods The investigation was conducted ...
OBJECTIVE: To delineate clinical characteristics useful for identifying children with liver failure due to accidental paracetamol overdose. DESIGN: Retrospective review of medical records of all patients admitted from 1985 to 1998 with fulminant hepatic failure. SETTING: Royal Alexandra Hospital for Children...
Clinical signs of hepatic damage (jaundice, abdominal pain, hepatic tenderness) and increased liver enzymes do not become apparent for 24–48 h after the overdose. Hepatic failure may ensue 2–7 days later; and is best monitored using prothrombin time. The plasma concentration of paracetamol is ...
Purpose To evaluate reported ingested dose of paracetamol as a risk assessment tool in acute paracetamol overdose. Methods Data was retrospectively obtained from a clinical toxicology database linked to one Australian and two United Kingdom hospitals. Plasma paracetamol concentrations (PPCs) of adult pa...
It is a promising candidate to be introduced into routine clinical practice and as a potential POCT for paracetamol overdose, enabling informed treatment decisions beyond traditional settings (e.g. in prisons, community pharmacies and general practitioner surgeries), which can lead to reduced ...
Acetaminophen (paracetamol) is a widely used nonopioid, non-NSAID analgesic that is effective against a variety of pain types, but the consequences of overdose can be severe. Because acetaminophen is so widely available as a single agent and is increasingly being formulated in fixed-ratio combinati...
Barbiturates are lethal when taken in overdose, because they induce respiratory depression. In addition to intentional suicide attempts, accidental or unintentional overdoses are common. Barbiturates in home medicine cabinets are a common cause of fataldrug overdosesin children. As...
Clinical features Most patients will initially present with no symptoms, or only mild gastrointestinal symptoms. Massive overdose is rare, but may cause coma and metabolic acidosis. Four chronological phases are described in cases of significant acute overdose: ...
ACLF due to acetaminophen overdose must be recognized and clearly differentiated from ALF on healthy liver because both conditions may show differences in clinical outcome and possibly require different therapeutic options, assuming a less favorable course of ACLF compared to ALF. Members of all Acute ...