Local inflammation triggers fibrogenesis, in which hepatic stellate cells play a major role. Cirrhosis is facilitated by external factors, such as chronic alcohol consumption and viral co-infections. Patients with cirrhosis are at high risk of developing hepatocellular carcinoma. The role of HCV ...
Hepatitis C virus (HCV) infection is a major cause of chronic progressive liver disease, including its long-term sequelae, i.e.cirrhosisandhepatocellular carcinoma[1]. Although some pathological features, such assteatosis, suggest a direct effect ofHCVon cellular constituents, most liver damage is ...
Coppage WS, Island DP, Cooner AE, Liddle GW (1962) The metabolism of aldosterone in normal subjects and in patients with hepatic cirrhosis. J Clin Invest 41: 1672–1680 Article PubMed CAS Google Scholar Dumont AE, Witte MH (1966) Contrasting patterns of thoracic duct lymph formation in he...
Local inflammation triggers fibrogenesis, in which hepatic stellate cells play a major role. Cirrhosis is facilitated by external factors, such as chronic alcohol consumption and viral co-infections. Patients with cirrhosis are at high risk of developing hepatocellular carcinoma. The role of HCV ...
Liver cirrhosis is a major cause of morbidity and mortality worldwide, mainly due to complications of portal hypertension. In this article, we review the current understanding on the pathophysiology, the diagnostic criteria and the available therapeutic options for patients with emerging hepatic syndromes...
Acute renal failure is frequently observed in patients with ascites and alcoholic cirrhosis of the liver. In the absence of any discernible anatomic or clinical cause for the renal failure, the decrease in renal perfusion is usually associated with significant arterial hypovolemia. If there is no co...
Recently, we have demonstrated that the hepatic Na-sensitive mechanism plays an important role in maintaining Na homeostasis. If this mechanism is impaired in liver cirrhosis, a disarrangement of body fluid homeostasis will occur. To tes... H Morita,K Tanaka,T Matsuda - 《Pathophysiology》 被引...
NAFLD may lead to non-alcoholic steatohepatitis (NASH) with possible evolution towards cirrhosis and hepatocellular carcinoma. In addition to steatosis, NASH is characterized by necroinflammation and fibrosis. While the presence of simple steatosis can be assessed by imaging studies, the occurrence of ...
Its relevance comes from the fact that it determines most complications leading to death or liver transplantation in patients with cirrhosis of the liver: bleeding from esophageal or gastric varices, ascites and renal dysfunction, sepsis and hepatic encephalopathy. Portal hypertension results from ...
Kircheis G, Nilius R, Held C, Berndt H, Buchner M, Gortelmeyer R, Hendricks R, Kruger B, Kuklinski B, Meister H, Otto HJ, Rink C, Rosch W, Stauch S. Therapeutic efficacy of l-ornithine-l-aspartate infusions in patients with cirrhosis and hepatic encephalopathy: Results of a placebo-...