The transformed HSC synthesize α-smooth muscle actin (α-SMA) and extracellular matrix proteins such as collagen type 1. Therefore, it is thought that HSC aredoi:10.1053/j.gastro.2009.07.017Caroline TaylorElsevier Inc.Gastroenterology
Pathophysiology of ascites formation. Ascites formation in patients with cirrhosis of the liver is dependent on local factors that preferentially localize any fluid retention to the peritoneal ... FJ Dudley - 《Gastroenterology Clinics of North America》 被引量: 64发表: 1992年 REVIEW: The controversy...
Hepatitis C virus (HCV) infection is a major cause of chronic progressive liver disease, including its long-term sequelae, i.e.cirrhosisandhepatocellular carcinoma[1]. Although some pathological features, such assteatosis, suggest a direct effect ofHCVon cellular constituents, most liver damage is ...
Although the role of the hepatic nervous system in liver homeostasis is increasingly appreciated, much remains unknown about the specific mechanisms by which hepatic nerves influence and are influenced by liver diseases. Both human and rodent livers are innervated by the autonomic nervous system (ANS)...
such as T and B cells.Disruption of the hepatic immune system can cause autoimmune hepatitis, steatohepatitis, cirrhosis, and liver cancer [15]. Although the positional relationships between the nerves and immune cells in the liver are unclear, the role of neuroimmunology in liver diseases has bee...
The presence of spur cells in peripheral blood (acanthocytosis) is a common feature of a heterogeneous variety of acquired and inherited disorders. Historically, spur cell anemia has been associated with advanced alcoholic liver cirrhosis, but it is also seen in other types of severe liver disease...
Hepatocellular carcinoma (HCC) is a primary malignancy of the liver (see the image below) that occurs predominantly in patients with underlying chronic liver disease and cirrhosis. However, up to 25% of patients have no history of cirrhosis or risk factors for it. Large hepatocellular carcinoma....
Liver cirrhosis. Blood pressure >170/110 mm Hg. Current chronic daily treatment with an orally administered steroid at a dose equivalent to ≥10 mg of orally administered prednisolone. Pregnancy or breastfeeding. Known galactose intolerance, total lactase deficiency or glucose–galactose malabsorptio...
2004). The penetrance of single ABCB11 variants in BRIC-2 is variable as shown in siblings with the ABCB11-mutation p.G374S: while the brother developed liver cirrhosis, the sister experienced self-limiting jaundice with pruritus (Stindt et al. 2013). Intrahepatic cholestasis of pregnancy ...
It covers a wide spectrum of pathological conditions, extending from simple steatosis (NAFLD, deposit of fat in hepatocytes) to nonalcoholic steatohepatitis (NASH, characterized by the presence of 5% hepatic steatosis and inflammation with hepatocellular damage, with or without fibrosis), cirrhosis, ...