Finally, several data also support a primary role of genetic factors. A few gene polymorphisms have also been associated with the risk of nonalcoholic fatty liver disease development and nonalcoholic steatohepatitis progression to more fibrosis and advanced liver disease. In a few cases (e.g., ...
Liver steatosis without alcohol consumption, namely, nonalcoholic fatty liver disease (NAFLD), is a common hepatic condition that encompasses a wide spectrum of presentations, ranging from simple accumulation of triglycerides in the hepatocytes without any liver damage to inflammation, necrosis, ballooning...
Summary This chapter contains sections titled: Introduction Pathogenesis and Risk Factors of ALD Generation of ROS in ALD Antioxidants RNS and their Reactivity with Ros Altered Proteasome Function in ALD The Unfolded Protein Response in ALD The Role of Alcohol-Induced Epigenetic Changes in Liver Injury...
Inherited disorders affecting fatty acid oxidation seriously compromise the function of muscle and other highly energy-dependent tissues such as brain, nerve, heart, kidney and liver. Such defects encompass a wide spectrum of clinical disease, presenting in the neonatal period or infancy with recurrent...
Non-alcoholic fatty liver disease (NAFLD) is likely the most common cause of liver disease in adults as well as in children and adolescents. Its occurrence is closely associated with obesity and insulin resistance. NAFLD may lead to non-alcoholic steatohepatitis (NASH) with possible evolution towar...
Pathophysiology of hepatitis C virus infection and related liver disease. Hepatitis C virus (HCV) infects over 170 million people worldwide. Chronic infection occurs in 50鈥 80% of cases and eventually leads to cirrhosis and hepat... JM Pawlotsky - 《Trends in Microbiology》 被引量: 427发表...
Diabetes is associated with a spectrum of liver diseases including nonalcoholic liver disease, steatohepatitis, and liver cirrhosis with their increased complications and mortality. Hepatitis C virus (HCV) and its associated liver cirrhosis has been associated with diabetes through insulin resistance. Crypt...
Pathophysiology and Pathogenesis of Visceral Fat Obesity As obesity reaches epidemic proportions, nonalcoholic fatty liver disease (NAFLD) is becoming a frequent cause of patient referral to gastroenterologists. ... YUJI,MATSUZAWA,IICHIRO,... - 《Annals of the New York Academy of Sciences》 被引量...
Mutations of the gene and pathophysiology of Charcot-Marie-Tooth X disease To test the hypothesis that fatty liver coexists with other metabolic abnormalities of the insulin resistance syndrome, and responds to their amelioration,... H Kawakami - 末梢神経 = Peripheral nerve 被引量: 100发表: 2006...
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 被引量: 41发表: 2014年 NAFLD and Chronic Kidney Disease Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in ...