"In our study, we observed a bi-directional association between fatty liver andcardiovascular disease," explained corresponding author Michelle Long, MD, assistant professor of medicine at Boston University School of Medicine (BUSM), who also is a gastroenterologist at Boston Medical Center (BMC). "...
Increased mortality in non-alcoholic fatty liver disease with chronic kidney disease is explained by metabolic comorbiditiesChronic kidney diseaseEpidemiologyliver cirrhosisLiver fibrosisMetabolic syndromeMortalitynon-alcoholic fatty liver diseaseBackground:There is a close association between non-alcoholic fatty ...
Fatty liverdisease refers to a clinicopathological syndrome in which triglycerides are excessively deposited and stored in the liver. Clinically, according to a personal history of long-term excessive drinking, fatty liver disease is divided into non-alcoholic fatty liver disease (NAFLD) and alcoholic ...
Fatty liver disease affects about 25% of the population in the United States. About 2% to 3% of the population has the progressive form of the disease — nonalcoholic steatohepatitis. "I suspect it is the nonalcoholic steatohepatitis patients who are primarily at risk for adverse outcomes," Dr...
IR is primarily responsible for the pathogenesis of T2D, NAFLD, and its more severe form, NASH (Holt et al.2006). The hepatic IR augmented by FFA influx and the overstimulation of pro-inflammatory cytokines and lipid intermediates in the liver is explained by the impediment to the phosphorylat...
The association of FLI with total cardiac adipose tissue was also strong and explained 32% of the variance; it is interesting that the variance was almost entirely explained by extra-pericardial fat. Figure 2. Relationship between fat depots and fatty liver index. OLS regression plots the ...
believed that the inflammation and damage of liver cells are caused by the toxic effects of the fatty acids released by fat cells, but fatty acids in the blood are elevated in both fatty liver and NASH. Perhaps the difference is explained by genetic susceptibility as suggested by preliminary ...
Conclusion High FLI (FLD) is associated with increased risks of mortality outcomes. The FLI-CVD mortality association can be largely explained by metabolic factors. Persons with FLD should be monitored for metabolic deterioration and extrahepatic morbidity to improve their prognoses. 展开 ...
Nonalcoholic fatty liver (NAFL) and its sequelae are growing health problems. We performed a genome-wide association study of NAFL, cirrhosis and hepatocellular carcinoma, and integrated the findings with expression and proteomic data. For NAFL, we utili
NAFLD is a fatty liver disease and the acronym stands for non-alcoholic fatty liver disease.1 It is a condition in which too much fat is stored in the liver cells. As explained in Section 1.a, your liver is a key organ involved in energy regulation. What your liver is not supposed to...