Clinical features and pathogenesis of severe malaria. Trends Parasitol. 2004; 20 :597–603. doi: 10.1016/j.pt.2004.09.006. [ Cross Ref ]Mackintosh CL, Beeson JG, Marsh K. Clinical Features and pathogenesis of severe malaria. Trends Parasitol. 2004; 20 :597–603. doi: 10.1016/j.pt....
Malaria, the disease caused byPlasmodiuminfection, is endemic to poverty in so-called underdeveloped countries.Plasmodium falciparum, the main infectiousPlasmodiumspecies in sub-Saharan countries, can trigger the development of severe malaria, including cerebral malaria, a neurological syndrome that claims t...
Severe falciparum malaria is commonly complicated by metabolic acidosis. Together with lactic acid (LA), other previously unmeasured acids have been implicated in the pathogenesis of falciparum malaria. In this prospective study, we characterised organic acids in adults with severe falciparum malaria in...
Pathogenesis of cerebral malaria: new diagnostic tools, biomarkers, and therapeutic approaches Cerebral malaria is a severe neuropathological complication of Plasmodium falciparum infection. It results in high mortality and post-recovery neuro-cognit... PK Sahu,S Sanghamitra,PK Behera,... - 《Frontie...
The life cycle, etiology, and epidemiology of P. falciparum are also presented. In addition, we provide a detailed discussion of the pathophysiology of severe, life-threatening complications of falciparum malaria such as cerebral malaria (CM), severe malarial anemia (SMA), hyperparasitemia, ...
vivax mortality | Naing C et al: P. vivax as severe malaria | P. vivax and choroquine resistance] How mosquitoes helped win the American Revolution By John R. McNeill | The mosquito has played a leading role in the rise and fall of empires throughout history By John R. McNeill...
Indeed, it is argued that the acute disease, including coma, caused by severe falciparum malaria has the same fundamental pathogenesis at a cellular level as severe sepsis, whether bacterial or viral in origin3.doi:10.1038/nri1858-c1Butcher, Geoff...
For example, many children who survive cerebral malaria (CM) suffer secondary long-term neurologic sequelae. Despite this clinical burden, perhaps surprisingly, the biological mechanisms involved in the pathophysiology of severe malaria remain relatively poorly defined. Interestingly, thrombocytopenia is a ...
Malaria associated (MA)-ALI/ARDS is a major clinical complication of severe malaria, which is characterized by a high mortality rate and resistance to therapy. HO-1 expression occurs in inflammatory cells in severe human malaria and may represent a therapeutic target in ani...
Phagocytosis of DVs not only deploys PMN away from merozoites, but also drives the cells into a state of functional exhaustion. This may be one reason for the enhanced susceptibility of patients with severe malaria toward systemic bacterial infections. Together, these findings indicate that the DV...