2024年2月,苏黎世大学的研究人员在Cell期刊发表了题为:Past, present, and future of CRISPR genome editing technologies(CRISPR基因组编辑技术的过去、现在和未来)的综述论文。 基因组编辑已经成为生命科学和人类医学的变革性力量,提供了...
2024 年 2 月,苏黎世大学的研究人员在Cell期刊发表了题为:Past, present, and future of CRISPR genome editing technologies(CRISPR 基因组编辑技术的过去、现在和未来)的综述论文。 基因组编辑已经成为生命科学和人类医学的变革性力量,提供了前所未有的机会来剖析复杂的生物过程和从根本上治疗遗传疾病。基于 CRISPR ...
2.Doudna, J.A., and Charpentier, E. (2014). Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Science 346, 1258096. 3.Martin Pacesa, Oana Pelea, and Martin Jinek, Past, present, and future of CRISPR genome editing technologies, Cell 187, February 29, 2024 4.M...
The DNA-binding domains of zinc finger (ZF) proteins were the first to be used as a genome editing tool, in the form of designed ZF nucleases and, more recently, transcription activator-like effector as well as the clustered, regularly interspaced, short palindromic repeats and CRISPR-...
This review commemorates the 40th anniversary of DNA sequencing, a period in which we have already witnessed multiple technological revolutions and a growth in scale from a few kilobases to the first human genome, and now to millions of human and a myriad of other genomes. DNA sequencing has ...
Despite considerable effort and significant therapeutic advances, age-related macular degeneration (AMD) remains the commonest cause of blindness in the developed world. Progressive late-stage AMD with outer retinal degeneration currently has no proven t
Furthermore, phage research has provided many techniques and reagents that underpin modern biology - from sequencing and genome engineering to the recent discovery and exploitation of CRISPR-Cas phage resistance systems. In this Timeline, we discuss a century of phage research and its impact on ...
Despite a large number of markers, phylogenomic methods used for squamates still have largely relied on reduced representations of the genome, and are less likely to incorporate differential evolutionary patterns and rates such as across coding and noncoding regions. The future of squamate phylogenomics...
In this review, we analyse the pharmacological aspects of these drugs as well as new therapeutic proposals by studying the past, present and future of the treatment of hypertriglyceridemia. It should also be noted that a concomitant hypolipidemic diet is necessary to support therapy. 2. Past ...
在此十年的重要节点上,来自加州大学伯克利分校的Jennifer A. Doudna等人在Science杂志上发表了一篇题为CRISPR technology: A decade of genome editing is only the beginning的综述,她们在这篇文章中呈现了十年来CRISPR基因编辑技术的成功,并讨论了当前最紧迫的挑战以及应对这些挑战所做出的的努力,强调了CRISPR在当前...