"We found that at sites where Cas9 was a 'dud' it stayed bound to the DNA strand and prevented the cell from initiating the repair process," Merrill said. The stuck Cas9 is also unable to go on to make additional cuts in DNA, thus limiting the efficiency of CRISPR, he said. Merrill,...
BLENDER is a companion program to the DISCOVER-Seq assay to identify off-target CRISPR/Cas editing sites from MRE11 ChIP-Seq experiments described in "Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq." BLENDER takes aligned bamfiles from the MRE11 IP experiment and (optionally...
“Vertex has a proven history of employing novel technologies to develop innovative medicines for diseases with high unmet medical needs, making them an ideal partner to expand the use of MTEM’s ETB platform for the...
have been extinct for more than 120 million years. But with new fossil analyses, scientists at the Smithsonian's National Museum of Natural History have discovered that these ancient lacewings were surprisingly similar to modern butterflies
Personalized Treatment Plans:Each patient is unique, and your medication plan should be tailored to your specific needs and health goals. A personalized approach considers your medical history, lifestyle, and preferences. This ensures that the chosen treatment aligns with your overall well-being. ...
When pollutants like petroleum hydrocarbons as one of the major origins of aquatic pollution, enter the environment, they alter the biological and/or physi
Loss-of-function variants in the dystrophin gene, a well-known cause of muscular dystrophies, have emerged as a mutational risk mechanism for autism spectr
The dataset contained 222 cases and 212 controls; however, no case-control data were provided for 11 cases. The majority of HCC patients had a history of hepatitis B infection (96.31%). 2.2. Mathematical Framework Machine-Learning Approaches For mathematical framework, we use the methodology in ...
Microfluidic devices have become a vastly popular technology, particularly because of the advantages they offer over their traditional counterparts. They have such a wide range of uses and can make complex tasks quite efficient. One area of research or work that has benefited greatly from the use ...
Microfluidic devices have become a vastly popular technology, particularly because of the advantages they offer over their traditional counterparts. They have such a wide range of uses and can make complex tasks quite efficient. One area of research or work that has benefited greatly from the use ...