passenger strand 的意思并非是将传统意义的passenger和strand 词义组合一起。它是医学上肿瘤学科里的一个专业用语,见“成熟miRNA链被称为引导链(guide strand),相对应的另一条链被称为过客链(passenger strand)”。---passenger ['pæsindʒə] 原义为:n. 乘客;旅客;过路人;[俚]碍手碍脚的人strand [...
passenger strand 的意思并非是将传统意义的passenger和strand 词义组合一起.它是医学上肿瘤学科里的一个专业用语,见“成熟miRNA链被称为引导链(guide strand),相对应的另一条链被称为过客链(passenger strand)”.---passenger ['pæsindʒə] 原义为:n.乘客;旅客;过路人;[俚]碍手碍脚的人strand [str...
passenger strand 的意思并非是将传统意义的passenger和strand 词义组合一起.它是医学上肿瘤学科里的一个专业用语,见“成熟miRNA链被称为引导链(guide strand),相对应的另一条链被称为过客链(passenger strand)”.---passenger ['pæsindʒə] 原义为:n.乘客;旅客;过路人;[俚]碍手碍脚的人strand [str...
RISC中的成熟miRNA链被称为引导链(guide strand),相对应的另一条链被称为过客链(passenger strand)。最小的RISC至少包 …zhidao.baidu.com|基于5个网页 2. 链中与靶序列相同那条 ...ced silence complex),此时,双链中与靶序列相同那条(passenger strand)被降解,与靶序列互补的一条(guide strande…wenwen.so...
RISC中的成熟miRNA链被称为引导链(guide strand)，相对应的另一条链被称为过客链(passenger strand)。最小的RISC至少包括下列物质：Argonaute (Ago) protein、Dicer以及TRBP，而RISC还可以和许多辅助蛋白相互作用[6]。一旦成熟miRNA的guide strand被装载进入RISC，它将会和其靶mRNA的 3’ UTR结合，从而...
Cleavage of the siRNA passenger strand during RISC assembly in human cells. EMBO Rep. 2006; 7 :314–320. doi: 10.1038/sj.embor.7400637. [ Cross Ref ]Leuschner PJ, Ameres SL, Kueng S, Martinez J. Cleavage of the siRNA passenger strand during RISC assembly in human cells. EMBO Rep. ...
The processing of the pre-miRNA hairpin generates a miRNA duplex, which consists of a miRNA (guide strand) and a miRNA* (passenger strand). miR-31 is an oncogenic miRNA and is up-regulated in oral squamous cell carcinoma (OSCC). miR-31* shows a high level of conservation across species...
Interestingly, microRNA-27a passenger strand (also call microRNA-27a*) in infarcted cardiac tissues and extracellular exosomes shows a relatively high abundance which normally undergoes intracellular degradation (Figure. 1). However, the role of microRNA-27a* in the onset and progression of CHF ...
Ago2 then cleaves the siRNA passenger strand, thereby liberating the single-stranded guide. For siRNAs, virtually all RISC is assembled through this cleavage-assisted mechanism. In contrast, passenger-strand cleavage is not important for the incorporation of miRNAs that derive from mismatched duplexes...
Cleavage of the siRNA passenger strand during RISC assembly in human cells Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Accumulation of driver and passenger mutations during tumor progression.