NF-kB mediates radio-sensitization by the PARP-1 inhibitor, AG-014699. Oncogene. 2012; 31 :251–264.J E Hunter,E Willmore,J A E Irving,Z Hostomsky,S J Veuger,B W Durkacz.NF-κB mediates radio-sensitization by the PARP-1 inhibitor, AG-014699.Oncegene. 2011...
PARP-1 also acts a transcriptional coactivator of nuclear factor kappa B (NFKB). The NFKB is a ubiquitous transcription factor that controls the expression of genes encoding cell adhesion molecules, growth factors, cytokines, and some acute phase proteins. Inappropriate activation of NFKB has been...
The molecular cooperation between Snail1 and NF-kB in transcription activation provides a new insight into how Snail1 can modulate a variety of cell programs. 展开 关键词: E-cadherin Epithelial-mesenchymal transition Fibronectin p65NF-kB PARP1 Snail1 ...
6. PARP1通过激活NF-kB-P65转录促进KIT表达 PARP1在参与DNA修复和转录的几个蛋白上形成分支多聚(ADP)核糖(PAR)聚合物,其中,PARP1是NF-kB转录调节复合物的关键成分。因此,研究者推测PPFIA1通过涉及PARP1、P65和KIT的轴参与白血病的生长。与假设一致,在K562细胞中强制表达PARP1导致P65表达水平上调,而使用奥拉帕尼(...
The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-kappaB in inflammatory disorders. Cell Mol Life Sci 2002; 59: 1534–1553. 43 Koc A, Batar B, Celik O, Onaran I, Tasan E, Kanigur-Sultuybek G. Polymorphism of the NFKB1 affects the serum inflammatory ...
Conclusions We suggest that, PARP-1 and NFkB1 gene polymorphisms may be risk factors for developing Graves Disease and Ophthalmopathy. 展开 关键词: Cytokine Graves Disease Graves Ophthalmopathy PARP-1 Polymorphism DOI: 10.1016/j.gene.2014.06.038 被引量: 28 ...
76, 77 Studies performed in primary AML blasts78 and tumor cell lines79, 80 revealed that the PARPi cytotoxic effect could be due to upregulation of death receptor 5 (DR5) and FS-7-associated surface antigen (FAS) death receptors that respectively requires the activation of SP1 and NF-KB...
The same experiments with bacterially expressed and purified subunits of NF-κB revealed the same result (see Fig. 5 C). Download: Download high-res image (183KB) Download: Download full-size image Figure 5. Mapping of the interaction domains on PARP-1 and the double mutated PARP-1 are ...
Challenge with Aβ25–35is also able to activate NF-kBviaPARP-1, as demonstrated by NF-kB impairment upon MC2050 treatment. Moreover, Aβ25–35viaPARP-1 induces a significant increase in the p53 protein level and a parallel decrease in the anti-apoptotic Bcl-2 protein. These overall ...
Consistent with a previous report (23), PARP-1 mRNA upregulation was associated with increased NF-κB expression Table 1. Relative mRNA expression of upstream and downstream effectors of PARP-1/NF-kB expression Transcript Control group Hyperglycemia group P53 1.00 ± 0.04 1.23 ± ...