We have previously developed an OI approach for early detection of oral cancer that targets the DNA repair enzyme PARP1. PARP1 plays a central role in initiating the DNA damage repair response (DDR), especially for single-strand breaks [22,23]. PARP1 expression is strongly increased in many ...
The normal function of PARP1 is the routine repair of DNA damage. Activated by DNA strand breaks, the PARP1 is cleaved into an 85 to 89-kDa COOH-terminal fragment and a 24-kDa NH2-terminal peptide by caspases during the apoptotic process. The appearance of PARP fragments is commonly ...
demonstrated that the depletion of either PARP-1 or Mitofilin, which abrogates the mitochondrial localization of the enzyme, leads to the accumulation of mtDNA damage. Finally, we show that DNA ligase III, known to be required for mtDNA repair, participates in a PARP-1-containing complex bound ...
DNA damage shuts down genome-wide transcription to prevent transcriptional mutagenesis and to initiate repair signalling, but the mechanism to stall elongating RNA polymerase II (Pol II) is not fully understood. Central to the DNA damage response, poly(ADP-ribose) polymerase 1 (PARP1) initi...
DNA ADP-ribosyltransferase PARP1, ARTD1, ADPRT1, ADPRT 1, ADPRT Print datasheet MSDS Validation Data Gallery Filter: AllWBIPIHCIF-PIF/ICCFC (Intra) WB analysis using 13371-1-AP Jurkat cells (25 μg/lane) were subjected to SDS PAGE followed by western blot with 13371-1-AP (PARP1 antib...
DNA ADP-ribosyltransferase PARP1, ARTD1, ADPRT1, ADPRT 1, ADPRTOverview Tested Applications Product Information Publications (7) Protocols Print datasheet MSDS Validation Data Gallery Filter: AllWBIPIHCIF/ICCFC (Intra) WB analysis using 22999-1-AP Various lysates were subjected to SDS PAGE ...
Applications Reported: This HC2R8 antibody has been reported for use in immunoblotting (WB).^M^MApplications Tested: This HC2R8 antibody has been tested by immunoblotting of staurosporine-treated Jurkat cells. This can be used at less than or equal to 0.1 µg/mL. It is recommended that ...
货号436400 100 µg CNY4,980.00 查看价格 下单后预计有货时间 03-Feb-2025 数量 批量或定制请求 性能保障 抗体检测数据 (10) 已发表图片 (9) 高级验证 (4) Application Created with Sketch. 图:1/23 PARP1 Antibody (436400) in ICC/IF Immunofluorescence analysis of PARP was done on 70% confluent...
PARP1 (poly(ADP-ribose) polymerase 1) is a nuclear enzyme catalyzing the poly(ADP-ribosyl)ation of many key proteins in vivo. The normal function of PARP1 is the routine repair of DNA damage. Activated by DNA strand breaks, the PARP1 is cleaved into an 85 to 89-kDa COOH-terminal frag...
货号MA5-15607 100 µL CNY4,976.00 查看价格 下单后预计有货时间 11-Feb-2025 数量 批量或定制请求 性能保障 说明书 实验方案 技术支持 Application Created with Sketch. 图:1/2 PARP1 Antibody (MA5-15607) in WB Western blot analysis of PARP using PARP monoclonal antibody (Product # MA5-15607)...