AHC MEDIANeurology Alert
MOTOR AND COGNITIVE PROFILES DIFFER BETWEEN LEWY BODY DEMENTIA AND PARKINSON'S DISEASE IN A PAIRED COMPARISON STUDY Olfactory dysfunction and REM sleep behavior disorder (RBD) are recognized as pre-motor symptoms of Parkinson's disease (PD). Cognitive dysfunction is observed at a high rate even in...
REM Sleep Behavior Disorder in Parkinson's Disease, Dementia with Lewy Bodies, and Multiple System Atrophy REM sleep behavior disorder in Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. In: Bedard M, Agid Y, Chouinard S, Fahn S, Korczyn A, Lesperance P, editors...
Parkinson’s disease-dementia PET: Positron emission tomography PSEN1: Presenilin 1 p-tau: Phosphorylated tau RBD: REM sleep behavior disorder SN: Substantia nigra SNc: Substantia nigra pars compacta SNCA: α-Synuclein gene SPECT: Single-photon emission computed tomography TH: Tyrosine ...
Dementia with Lewy bodies (DLB) is the second leading cause of neurodegenerative dementia, representing 10–15% of dementia cases [16]. DLB is characterized by fluctuating cognitive deficits, visual hallucinations, REM sleep behavior disorder (RBD), and parkinsonism [17]. Clinical aspects are close...
In contrast, the reduced sensitivity to epinephrine in PD patients exacerbates symptoms of dementia, depression, bradykinesia, tremor, and ankylosis34, leading to a significant reduction in daily activities, and PD, as a chronic disease, may ultimately lead to the patient’s loss of mobility as ...
Dementia in Parkinson's disease (D-PD) worsens the course of PD, and it is associated with a decrease in the quality of life of patients and caregivers, as well as with elevated costs for patient care, and, as a consequence, leads to a significant cost increase in the health management...
Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder. disease in idiopathic REM sleep behavior disorder is substantial, with the majority of patients developing Parkinson disease and Lewy body dementia.doi... RB Postuma,JF Gagnon,M Vendette,... - 《Neurology》 ...
Treatment of Parkinsonism is often complicated by drug-induced psychosis and reduced levodopa responsiveness. Cognition, alertness, attention, as well as apathy or aggressive behavior have been shown to respond to treatment with cholinesterase inhibitors in randomized controlled trials both in DLB and PDD...
The domains of delusion, hallucination, agitation and aggression, anxiety, irritability and lability, and aberrant motor behavior were associated with caregiver stress. After controlling for age and other potential confounding variables, total NPI score was significantly associated with caregiver burden. ...