Parkinson’s disease is caused by the deposition of Lewy body in substantia nigra (part of basal ganglia) leads to the death of dopaminergic neurons and subsequent symptoms from dopamine deficiency. 1.Lewy body意为"路易体",主要是由一种叫做alpha synuclein"α...
according to the National Institute on Aging. Other conditions also share multiple symptoms with PD, resulting in misdiagnosis or a late diagnosis when symptoms have already become severe. Since the disease is most common in older adults, early symptoms are also...
Parkinson's disease (PD) is a common, disabling, neurodegenerative disorder. In addition to classical motor symptoms, non-motor features are now widely accepted as part of the clinical picture, and cognitive decline is a very important aspect of the disease, as it brings an additional significant...
Parkinson's disease: from monogenic forms to genetic susceptibility factors Research in Parkinson's disease (PD) genetics has been extremely prolific over the past decade. More than 13 loci and 9 genes have been identified, but the... S Lesage,A Brice - 《Human Molecular Genetics》 被引量:...
"For those of us who have Parkinson's, we don't have a cure,” Jaffe said. “I mean, if we can slow the disease or change the outcome, we'll take what we can get. And so I'll be cycling for as long as I have to." ...
Background: Even with numerous studies the cause of Parkinsons disease (PD) remains elusive. It has been hypothesized that interactions between genetic and environmental factors may play an important role in the pathogenesis of PD. Objectives: To examine the gene-gene and gene-environment interaction...
Abnormal accumulation of α-synuclein and mitochondria dynamics dysfunction are considered to be implicated in the pathogenesis of Parkinson's disease. However, the underlying mechanisms how α-synuclein abnormal accumulation causes mitochondrial dynamics dysfunction remains unclear. Here, we demonstrate that ...
Farnsworth-Munsell 100 Hue test (FMT) error scores and peg insertion abilities significantly differ between Parkinsons disease (PD) patients and controls. Both tasks ask for performance of voluntary movements. The objective of this study was to demonstrate a relation between FMT error scores and peg...