Parkinson's disease (PD) is a severe disease with many symptoms, including speech disorders. Although many methods exist to treat some of PD's symptoms, therapies for speech impairment are not effective and satisfactory, resulting in an open area of research. The current project aims at taking...
according to the National Institute on Aging. Other conditions also share multiple symptoms with PD, resulting in misdiagnosis or a late diagnosis when symptoms have already become severe. Since the disease is most common in older adults, early symptoms are also...
Parkinson’s disease is caused by the deposition of Lewy body in substantia nigra (part of basal ganglia) leads to the death of dopaminergic neurons and subsequent symptoms from dopamine deficiency. 1.Lewy body意为"路易体",主要是由一种叫做alpha synuclein"α...
"It's a tough diagnosis to have to hear because there's a lot of stigma associated with this disease," Jaffe said. However, a new kind of treatment is showing a reduction in symptoms for Parkinson’s patients. Jay Alberts, a neuroscientist and Cleveland Clinic researcher, has conducte...
Parkinson's disease (PD) is a common, disabling, neurodegenerative disorder. In addition to classical motor symptoms, non-motor features are now widely accepted as part of the clinical picture, and cognitive decline is a very important aspect of the disease, as it brings an additional significant...
IMPORTANCE OF THE FIELD: Levodopa (LD) is an efficient drug for patients with Parkinson's disease (PD). Its short half-life supports peaks and troughs. These plasma fluctuations support alternating stimulation of striatal postsynaptic dopamine receptors and thus onset of motor complications. They ...
While most reported that OlfH were infrequent, 18% (n=2) reported hallucinations lasting >1 hour and found them unpleasant and upsetting.Conclusions: Non-motor symptoms of PD are often missed in routine clinical practice and have far-reaching implications in patient care. OlfH tend to be ...
Objective: To describe collected outcomes from a large-scale registry of a Deep Brain Stimulation (DBS) system capable of Multiple Independent Current Source Control (MICC) used for the management of symptoms of levodopa-responsive Parkinson's disease (PD).Background: The effectiveness of DBS for ...