Parkinson’s disease is caused by the deposition of Lewy body in substantia nigra (part of basal ganglia) leads to the death of dopaminergic neurons and subsequent symptoms from dopamine deficiency. 1.Lewy body意为"路易体",主要是由一种叫做alpha synuclein"α...
IMPORTANCE OF THE FIELD: Levodopa (LD) is an efficient drug for patients with Parkinson's disease (PD). Its short half-life supports peaks and troughs. These plasma fluctuations support alternating stimulation of striatal postsynaptic dopamine receptors and thus onset of motor complications. They ...
Parkinson's disease (PD) is a common, disabling, neurodegenerative disorder. In addition to classical motor symptoms, non-motor features are now widely accepted as part of the clinical picture, and cognitive decline is a very important aspect of the disease, as it brings an additional significant...