(grant no. P30 CA23100 from the NCI). This work was supported by grants from the ACS (grant no. RSG-09-282-01-CSM) and NCI (grant nos 1RO1CA168689, 1R01CA174869, 1R01CA206880 and 1R21CA191442) to J.Y., and the NIH (grant nos NIH R35 GM122523 and NIH P01 DK054441)...