HER2 Pan-Tumor 大陆—香港专家研讨会 ADC药物在HER2实体瘤种的应用进展。 抗HER2药物作为靶向治疗时代的代表性药物,对乳腺癌和胃癌的治疗影响深远。伴随生物制药技术的发展,更加高效的新型药物不断推出,其中新一代ADC药物为抗HER2治疗带来了革命性变化,不仅在传统抗H...
Human epidermal growth factor receptor 2 (HER2) protein expression or gene amplification is a significant predictive biomarker for identifying patients with cancer, who may benefit fromHER2-targeted therapy. The aim of this study was to survey the proportion of patients who hadHER2aberration and to ...
In the overall population, there was a trend toward shorter OS forHER2amp+vsHER2amp pts (PAN: 23.0 vs 36.3 mo; HR, 1.57; 95% CI: 0.96–2.57; BEV: 26.7 vs 31.6 mo; HR, 1.41; 95% CI: 0.79–2.52). Median PFS and RR were similar between pts withHER2amp+andHER2amp in PAN or ...
Efficacy and safety of neoadjuvant sintilimab in combination with FLOT chemotherapy in patients with HER2-negative locally advanced gastric or gastroesophageal junction adenocarcinoma: an investigator-initiated, single-arm, open-label, phase II study. Int J. Surg. 110, 2071–2084 (2024). Article ...
Breast cancer is highly heterogeneous with five different molecular subtypes identified (Basal, Luminal A, Luminal B, HER2 and Normal-like) and are known to be metabolically very heterogeneous as well116. A recent multi-omics study conducted on breast cancer samples also corroborated the intert...
DDR1 promoted development in orthotopic glioblastoma mouse models and human ER-positive, HER2-negative breast cancer and reduced the efficacy of chemotherapy agents by activating the AKT signaling pathway in these tumor cells11,12. However, metformin could inhibit the expression of p-Akt and increase...
In breast cancer, the PAM50 molecular subtypes, such as luminal A and B had the highest median iRIS scores, whereas the HER2 and basal subtypes had the lowest median iRIS, which were significantly different (P < 0.001; Supplementary Fig. 2). iRIS correlates with radiotherapy outcomes in non...
In breast invasive carcinoma (BRCA), APOA1 mRNA expression was lowest in Her2. The primitive type has the highest APOA1 mRNA expression in LUSC. The chromosome instability (CIN) type had the highest STAD's APOA1 mRNA expression (Fig. 2C). Download: Download high-res image (1MB) Download...
We explored the association of SGLT2-coding geneSLC5A2with the transcriptomic, genomic, immunological landscape and outcomes in a subset of solid tumors.Methods:Breast ([N = 5623], HR+HER2- [6044] or TNBC [3040]), Colorectal carcinoma (CRC, 15425), NSCLC ([21603], Adenocarcinoma [AC, ...
In this large, real-life pan-cancer patient cohort, our results indicate thatPIK3CA/PIK3R1mutations are widely spread, and plead in favour of evaluating the efficacy of PI3K inhibitors outside of ER+/HER2 mBC and outside of hotspot mutations....