Use Xenium Explorer Demo, a preview of the desktop app, to explore a Xenium In Situ dataset from a 0.4 cm² human breast cancer FFPE section using a 280-gene Xenium Human Breast Gene Expression Panel with 33 additional custom genes.
et al. Spatial deconvolution of HER2-positive breast tumors reveals novel intercellular relationships. Preprint at bioRxiv https://doi.org/10.1101/2020.07.14.200600 (2020). Newman, A. M. et al. Determining cell type abundance and expression from bulk tissues with digital cytometry. Nat. Biotechnol...
supporting the tenet that NK cells are critical for tumor control despite their relatively low frequency (reviewed in [8,9]). In experimental mouse models of HER2+breast cancer, NK cells were reported to significantly contribute to the efficacy of the anti-...
In particular, human epidermal growth factor receptor 2-positive (HER2+) breast cancers and squamous cell lung cancers showed positive rates of 16.0% (four out of 25 cases) and 14.6% (seven out of 48 cases), respectively, which were significantly higher than the average (Fisher’s exact ...
samples against 51 primary breast tumor samples representing all subtypes (ncbi gse18864). tnbc is characterized by the lack of expression of estrogen receptor (er), progesterone receptor (pgr), and the human epidermal growth factor receptor 2 (erbb2, or her2) [ 30 ]. it largely overlaps ...
Basal-like breast cancer originates in luminal progenitors, frequently with an altered PI3K pathway, and focally in close association with genetically altered myoepithelial cells at the site of tumor initiation. The exact trajectory behind this bi-lineag
Mc Ilroy M, Fleming FJ, Buggy Y, Hill AD, Young LS: Tamoxifen-induced ER-alpha-SRC-3 interaction in HER2 positive human breast cancer; a possible mechanism for ER isoform specific recurrence. Endocr Relat Cancer. 2006, 13 (4): 1135-1145. 10.1677/erc.1.01222. Article CAS PubMed Google ...
IHC typically identifies and quantifies one biomarker of interest at a time and answer specific questions, such as whether or not a particular breast tumor biopsy contains cells that overexpress human epidermal growth factor receptor 2 (HER2) or not. IHC stains require manual interpretation by ...
Gene set enrichment analysis for cis- and trans-acting lncRNAs showed enrichment for breast cancer signatures driven by master regulators of breast carcinogenesis. Interestingly, the lncRNA HOTAIR was significantly overexpressed in the HER2-enriched subgroup, while the lncRNA HOTAIRM1 was significantly ...
1B). Significantly, on chromosome 17, CDK12 is frequently co-amplified with HER2 in approximately 90% of HER2-positive breast cancer cases [12]. Moreover, this co-amplification pattern is prevalent in HER2-positive gastric cancers, where it is associated with poor prognostic outcomes [13]. ...