To evaluate the performance of reported biomarkers for cancer early screening in real world, we launched an integrative study by Fudan University and SInglera for pan-cancer early detectiON (FuSion) project since 2021. Method: The FuSion Project (NCT05159544) is a prospective and multicenter cohort...
Universal cancer screening based on circulating DNA, proteins, metabolites, or other combinations has the potential to revolutionize early cancer detection, especially for cancers with no available screening modalities. Two recent publications highlight the potential benefits and limitations of single-test,...
Evidence of variable quality from 6 diagnostic test accuracy studies indicates that the Pan-Canadian Early Detection of Lung Cancer (PanCan) model may perform better at determining which lung nodules identified by low-dose CT are cancerous compared to the Lung Imaging Reporting and Data System. Ho...
The Ethics Committee of Yancheng Third People's Hospital, the Sixth Affiliated Hospital of Nantong University in Jiangsu Province, China, approved this research. Results Differential expression of HS6ST2 between tumor and para-carcinoma tissues We initially conducted a pan-cancer analysis of 33 maligna...
Sp1, a transcription factor, regulates essential cellular processes and plays important tumorigenic roles across diverse cancers. However, comprehensive pan-cancer analyses of its expression and potential immunomodulatory roles remain unexplored. Utilizi
RAB3B is essential for the transportation and secretion within cells. Its increased expression is linked to the development and progression of various malignancies. However, understanding of RAB3B’s involvement in carcinogenesis is mostly limited to spe
early detection Abbreviations DFS disease-free survival dUTPase deoxyuridine triphosphate nucleotidohydrolase EBV Epstein–Barr virus EBNA1 EBV nuclear antigen 1 NAPPA nucleic acid programmable protein arrays NPC nasopharyngeal carcinoma PBST PBS with 0.2% Tween-20 RAPID-ELISA rapid antigenic protein in situ...
First-of-its-kind one-for-all cancer mutation detection test SHENZHEN, China,Dec. 19, 2022/PRNewswire/ -- SeekIn Inc, a leader in blood-based cancer early detection and monitoring technology, today announced CE (Conformité Européenne) Mark approval for PanCanSeek®Ca...
in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these ...
Interleukin 32 (IL32) is a pro-inflammatory cytokine that plays a key role in promoting sterile inflammation by modulating immune responses. However, the role of IL32 in various cancers remains unclear. This research aimed to investigate the correlation