The inhibitor bound to the GDP-loaded state of WT, G12C, G12D, G12V and G13D KRAS with high affinity (dissociation constant (Kd), 10–40 nM; Fig.1c), as determined by isothermal titration calorimetry (ITC) (Extended Data Fig.2a,b). By comparison, the affinity was 60–140 time...
Design: The mouse model consisted of orthotopic injection of 4 mammary cancer cell lines, giving rise to tumors with different metastatic potential. 67NR tumors showed no metastasis, 168FARN and 4T0 tumors had intermediate invasive potential, whereas 4T1 tumors led to lung metastasis. Thirty mice...
Schematic of lung colonisation assay using vital dye-stained SP1 knockdown (red) and control MDA-MB-231 cells (green) co-injected into the tail vein of NXG mice. Lungs were imaged 24 h post-injection, displaying representative images with a heatmap analysis using QuPath pixel mapping. Cell nu...
These two noninvasive techniques provide more clarity and reveal the minute details of the abdominal area compared to the regular X-ray exams. MRI Enterography involves injection of a contrast medium like Metamucil, barium or Golytely into the body followed by a MRI scan. CT Enterography combine...
Lange Zeit war die Beschreibung der chronischen Pankreatitiden verworren, da es an einer Definition der verschiedenen Pankreaserkrankungen fehlte. Während des im Jahre 1962 in Marseille abgehaltenen Symposions über die pathologisch-anatomischen Aspekte und die Ätiologie der Pankreatitis (H. ...
Schematic of lung colonisation assay using vital dye-stained SP1 knockdown (red) and control MDA-MB-231 cells (green) co-injected into the tail vein of NXG mice. Lungs were imaged 24 h post-injection, displaying representative images with a heatmap analysis using QuPath pixel mapping. Cell ...
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Tobacco leaves in the injection area were collected and fluorescence activity was measured using a luciferase assay kit (cat. no. DL101, Vazyme Biotech). The primers used in this section are shown in Supplementary Table 20. Tobacco leaf transformation assays to assess the impact of SVs on ...
Currently licensed SARS-CoV-2 vaccines are all delivered parenterally via intramuscular injection, which leads to some limitations for vaccine roll-out and potentially for protective efficacy (Table1). Needle use can reduce uptake due to the fear of needles, it can lead to needle-stick injuries;...
the method may further include the step of insert molding the base plate and the one or more side plates; the step of injection molding a web may include overmolding the web relative to the base plate and one or more side plates; and the step of injection molding a web may include co...