(Supplementary Fig. 2c–e). We further analysed the expression of monocyte chemoattractant protein 1 (MCP-1) and intracellular adhesion molecule 1 (ICAM-1) in the cardiac tissues as additional indicators of local inflammatory response activation. IL-6 is known to increase both MCP-1 and ICAM-...
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Colloid Interface Sci. 116, 50-58.Handa T,Matsuzaki E,Nakagaki M.Orientations of a Bifunctional Molecule, 16-(9-anthroyloxy)palmitic Acid, in Micelles and Liposomes. J. Colloid Interface Sci . 1987
Metabolic reprogramming is a hallmark of cancer. However, it is not well known how metabolism affects cancer progression. We identified that metabolic enzyme acyl-CoA oxidase 1 (ACOX1) suppresses colorectal cancer (CRC) progression by regulating palmitic acid (PA) reprogramming. ACOX1 is highly dow...
The simulations indicated that both ligands quickly enter the Oxy-Mb structure through a dynamic area called the "portal region" near the heme group, which forms the entry point for small molecule gaseous ligands like O 2 , CO and NO. The same phenomenon is not observed with Deoxy-Mb where...
Palmitic acid (PA) is the most abundant free fatty acid that could be found in the human body as well as diet [1]. Abnormal increase of PA in tissues will break tissue homeostasis, increase lipid toxicity, and lead to the occurrence of related metabolic diseases, such as obesity [2], ...
The result shows that the PA molecule was grafted onto the SAN, SAN-g-PA were obtained successfully. The crystalline morphology and crystal structures of the synthesized SAN-g-PA are different from palmitic acid and SAN. As novel SSPCMs, SAN-g-PA possess suitable phase transition temperature,...
Fatty acidAcylcarnitinesMyoglobin, besides its role in oxygen turnover, has gained recognition as a potential regulator of lipid metabolism. Previously, we confirmed the interaction of fatty acids and acylcarnitines with Oxy-Myoglobin, using both molecular dynamic simulations and Isothermal Titration ...
Restoring palmitic acid availability, either through pharmacological inhibition of stearoyl-CoA desaturase 1 or a palmitic acid-enriched diet, significantly restores endothelial cilia and mitigates the progression of atherosclerosis. These findings thus uncover a previously unrecognized role of lipid droplets ...
Persistent elevation of plasma TNF-α is a marker of low grade systemic inflammation. Palmitic acid (PA) is the most abundant type of saturated fatty acid in human body. PA is bound with albumin in plasma and could not pass through endothelial barrier freely. Albumin-bound PA has to be tra...