The difference in BRCA2 -mutation frequencies between cases with and without family history of breast cancer was not statistically significant ( P =0.145), suggesting that family history is not a strong predictor of carrying a mutation in males. We observed a highly significant association of ...
BRCA mutation sta- tus has potential therapeutic implications, because those carrying such mutations have been shown to benefit from therapies that inhibit poly(ADP ribose)polymerase (PARP inhibitors).18,19 PALB2, a co-localizer and partner gene to BRCA2, is also proposed to be involved in ...