Mutation analysis of the PALB2 gene in unselected pancreatic cancer patients in the Czech Republic. Cancer Genet 2016;209:199-204.Borecka M, Zemankova P, Vocka M, Soucek P, Soukupo- va J, Kleiblova P, Sevcik J, Kleibl Z, Janatova M. Mutation analysis of the PALB2 gene in ...
Arnold J, Thibodeau SN, Gunawardena SR, Bapat B, Baron JA, Casey G, Gallinger S, Le Marchand L, Newcomb PA, Haile RW, Hopper JL, Jenkins MA (2012) Colorectal and other cancer risks for carriers and noncarriers from families with a DNA mismatch repair gene mutation: a prospective cohort...
PALB2 mutations were identified in 77 breast-pancreas cancer families, which included 22 probands with a personal history of both breast and pancreatic cancer.Mutations within the PALB2 gene are rare events that do not account for a substantial proportion of cancer susceptibility in breast-...
To the Editor PALB2 (partner and localizer of BRCA2 ) has been recently described as a breast cancer predisposing gene [ 1 , 2 ]. In the first report, PALB2 truncating mutations were identified in 10/923 (1.1%) English familial breast cancer cases [ 1 ]. Subsequent studies in Spanish...
Partner and localizer of BRCA2 (PALB2) was originally identified as a BRCA2-interacting protein that is crucial for key BRCA2 genome caretaker functions. It subsequently became clear that PALB2 was another Fanconi anemia (FA) gene (FANCN), and that monoallelic PALB2 mutations are associated...
Mono-allelic germline pathogenic variants in the Partner And Localizer of BRCA2 (PALB2) gene predispose to a high-risk of breast cancer development, consistent with the role of PALB2 in homologous recombination (HR) DNA repair. Here, we sought to define
Mutation map ofPLAB2gene Full size image TheBRCA1mutation cohort is associated with a higher proportion of advanced stages compared to those without. Additionally, theBRCA2-mutant patients show a higher incidence of family history of ovarian cancer, resulting in a significant difference in the numbe...
PALB2 was subsequently found as a tumor suppressor gene. Inherited heterozygosity for this gene is associated with an increased risk of cancer of the breast and other sites. Additionally, biallelic mutation of PALB2 is linked to Fanconi anemia, which also has an increased risk of developing ...
[6] Gronwald J, Cybulski C, Piesiak W, Suchy J, Huzarski T, Byrski T, Gorski B, Debniak T, Szwiec M, Wokolowczyk D, Matuszewski M, Sun P, Lubinski J, Narod SA. Cancer risks in first-degree relatives of CHEK2 mutation carriers: effects of mutation type and cancer site in proba...
Short report:Germline PALB2 mutation analysis in breast–pancreas cancer families 喜欢 0 阅读量: 10 摘要: Background Germline mutations in the PALB2 gene have been implicated in both breast cancer and pancreatic cancer susceptibility. The extent to which PALB2 mutations account for cancer ...