PALB2 gene mutation elevates risk of breast cancer four-foldtext editorEmerging Infectious Diseases
In this article the importance and the prevalence of the PALB2 gene is presented as well as the breast cancer risk is analyzed (based on various studies). To better manage and understand the risks we have detailed the newest monitoring and treatment options regarding a mutation in the PALB2...
Lubinski J, Narod SA. Cancer risks in first-degree relatives of CHEK2 mutation carriers: effects of mutation type and cancer site in proband. Br J Cancer. 2009 May 5;100(9):1508-12. doi: 10.1038/sj.bjc.6605038. PMID
Genetic epidemiology of early onset breast cancer. Risks for breast cancer when there is a family history of the disease are usually calculated using data from segregation analyses which favour a single dom... D Eccles,A Marlow,G Royle,... - 《Journal of Medical Genetics》 被引量: 1163发表...
Original Research Article © American College of Medical Genetics and Genomics PALB2 sequencing in Italian familial breast cancer cases reveals a high-risk mutation recurrent in the province of Bergamo Irene Catucci, PhD1,2, Paolo Peterlongo, PhD1,2, Sara Ciceri, MSc1,2, Mara ...
The prevalence of the PALB2 mutation in breast cancer varies across different ethnic groups; hence, it is of intense interest to evaluate the cancer risk and clinical association of the PALB2 mutation in Chinese breast and/or ovarian cancer patients. We performed sequencing with a 6-gene test...
Breast cancer tumour morphology can be suggestive of under- lying familial, if not heritable, risk. We recently reported that, in a population-based sample of 375 women with early-onset breast cancer cases with no known high-risk mutation in a breast cancer susceptibility gene, minimal sclerosis...
Ancestry-adjusted genomic analysis to identify known and novel associations with single and multiple cancer phenotypes. 10504#Background:Germline cancer risks are impacted by cancer type, stage, specific mutation, and ancestry. This study aims to determine the magnitude of g... V Joseph,V Ravichandr...
Prostate cancer risks for male BRCA1 and BRCA2 mutation carriers: a prospective cohort study. Eur Urol. 2020;77:24–35. Article CAS PubMed PubMed Central Google Scholar Annala M, Vandekerkhove G, Khalaf D, Taavitsainen S, Beja K, Warner EW, et al. Circulating tumor DNA genomics ...
Currently, few published data describe the cancer risks for carrying more than one mutation.18 Here, we assumed that the risks follow a dominant model, with the order of precedence being BRCA1, BRCA2, PALB2, CHEK2, ATM, and wild-type. Under this model, in the presence of a mutation ...