Thus, PAI-1 could serve as a potential prognostic biomarker of cardiac fibrosis and inflammation, as well as possible therapeutic target in inflammatory cardiomyopathies. FUNDING ACKNOWLEDGEMENT. Type of funding sources: Public grant(s) – EU funding. Main funding source(s): ERA-Net on ...
RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook PAI-1 Acronyms SERPINE1 A gene on chromosome 7q21.3-q22 that encodes a serine protease inhibitor that acts on tissue plasminogen activator (tPA) and urokinase, inhibiting fibrinolysis. ...
(1). These enzymes convert plasminogen to its active form, plasmin, and are thought to influence many biological processes inducing fibrinolysis, ovulation, embryonic development, inflammation, tumor metastasis, wound healing and angiogenesis (2). PAI-1 belongs to the SERine Protease INhibitor ...
Phagocytosis of apoptotic cells, also called efferocytosis, is an essential feature of immune responses and critical for the resolution of inflammation. Plasma and tissue levels of plasminogen activator inhibitor-1 (PAI-1), an inhibitor of fibrinolysis, are elevated in inflammatory conditions, including...
[2] Chia S,Ludlam CA,Fox KA,et al.Acute systemic inflammation enhances endothelium-dependent tissue plasminogen activator release in men.J Am Coll Cardio 1.2003;41:333～339 [3]高天理.张茁.温绍君,等.短暂脑缺血发作和脑梗死患者血浆vWF,tPA和PAI-1变化的临床对照研究,北京医学,2004;26(2):86～89...
In this study we explored the microRNAs responsible for the regulation of PAI-1 during LPS-stimulated inflammation in human aortic endothelial cells and su... Sujana,Katta,Santosh,... - 《Journal of Cellular Physiology》 被引量: 5发表: 2018年 Inhibition of Hydrogen Peroxide-Induced Human Umbili...
单核细胞和中性粒细胞的趋化在 特异性干扰PAI.1表达后明显减弱。单核细胞趋化siRAN+CSE刺激组与 ncRNA+CSE刺激组相比,siRAN+LPS刺激组与ncIⅢA+LPS刺激组相比, 均明显减弱(P均<0.01)。中性粒细胞趋化siRAN+CSE刺激组与 ncRNA+CSE刺激组相比,siI乙～N+LPS刺激组与ncRNA+LPS刺激组相比, 也同样显著减弱(P均<...
[3]Arndt PG,Young SK,Worthen GS.Regulation of lipopolysaccharide-induced lung Inflammation by plasminogen activator inhibitor-l through a jnk-mediated pathway[J].J Immunol,2005,175:4049-4059 . [4]Degryse B,Sier CF,Resnati M,et al.Pai-1 inhibits urokinase-induced chemo-Taxis by internalizing ...
BACKGROUND: Inflammation plays a pivotal role in atherosclerosis. In addition to being a risk marker for cardiovascular disease, much recent data suggest t... Devaraj,S. - 《Circulation》 被引量: 2186发表: 2003年 Stromal cells are the main plasminogen activator inhibitor-1-producing cells in hu...
Research fields: inflammation research, neurobiology, metabolism, signal pathway, immunology, infectious diseases, and other research. Delivery date: ELISA kit is ailable from stock Prompt: Our ELISA test kit is only for scientific research and experiment, and cannot be used for other purposes; Read...