Thus, PAI-1 could serve as a potential prognostic biomarker of cardiac fibrosis and inflammation, as well as possible therapeutic target in inflammatory cardiomyopathies.doi:10.1161/circ.144.suppl_1.11929Christian BaumeierFelicitas EscherGanna Aleshcheva...
Phagocytosis of apoptotic cells, also called efferocytosis, is an essential feature of immune responses and critical for the resolution of inflammation. Plasma and tissue levels of plasminogen activator inhibitor-1 (PAI-1), an inhibitor of fibrinolysis, are elevated in inflammatory conditions, including...
(1). These enzymes convert plasminogen to its active form, plasmin, and are thought to influence many biological processes inducing fibrinolysis, ovulation, embryonic development, inflammation, tumor metastasis, wound healing and angiogenesis (2). PAI-1 belongs to the SERine Protease INhibitor ...
Impact of endothelial microparticles on coagulation, inflammation, and angiogenesis in age-related vascular diseases This has the advantage of protecting the plasminogen activator from neutralisation by circulating plasminogen activator inhibitors (PAI1 and PAI2). Thrombolysis for deep venous thrombosis The ...
Introduction: Atrial fibrillation (AF) is currently the most common cardiac arrhythmia and is a major cause of morbidity and mortality. Inflammation and thrombogenesis plays a crucial role in the progression of atrial fibrillation. CD40-Ligand (CD40-L) and PAI-1 are mediators which are elevated ...
The action of PAI-1 on inflammation is related to the activation of the hemostatic system that directs the restructuring of tissue functions after injury. In this, inflammatory mediators such as interleukin 1 (IL-1), interleukin 6 (IL-6), tumor necrosis factor- α (TNF-α) and inflammatory...
[2] Chia S,Ludlam CA,Fox KA,et al.Acute systemic inflammation enhances endothelium-dependent tissue plasminogen activator release in men.J Am Coll Cardio 1.2003;41:333～339 [3]高天理.张茁.温绍君,等.短暂脑缺血发作和脑梗死患者血浆vWF,tPA和PAI-1变化的临床对照研究,北京医学,2004;26(2):86～89...
[3]Arndt PG,Young SK,Worthen GS.Regulation of lipopolysaccharide-induced lung Inflammation by plasminogen activator inhibitor-l through a jnk-mediated pathway[J].J Immunol,2005,175:4049-4059 . [4]Degryse B,Sier CF,Resnati M,et al.Pai-1 inhibits urokinase-induced chemo-Taxis by internalizing ...
The mechanisms by which PAI-1 contributes to inflammation have not been fully delineated. In the present experiments, we found that addition of PAI-1 to neutrophil cultures diminished the rate of spontaneous and TNF-related apoptosis-inducing ligand-induced apoptotic cell death. The effects of PAI...
Research fields: inflammation research, neurobiology, metabolism, signal pathway, immunology, infectious diseases, and other research. Delivery date: ELISA kit is ailable from stock Prompt: Our ELISA test kit is only for scientific research and experiment, and cannot be used for other purposes; Read...