Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. They are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation...
Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. They are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation...
Complete plasminogen activator inhibitor type 1 (PAI-1) deficiency is an exceedingly rare autosomal recessive bleeding disorder previously identified and reported in a large Old Order Amish (OOA) kindred in Indiana [Fay etal. Blood 1997; 90: 204]. Mouse models suggest that proteolysis via the ...
易栓症是指因各种遗传性或获得性因素,容易发生血栓形成和血栓栓塞的病理状态[1]㊂易栓症导致的血栓事件反复发生,会提高患者的致残率和致死率,严重危害身体健康㊂因为生理性抗凝蛋白基因突变导致蛋白抗凝血功能缺失,或促凝蛋白基因突变导致蛋白促凝功能增强,最终引起血栓性疾病[2]㊂而在遗传性血栓形成倾向患者中,...
An abundant literature suggests that the Plasminogen Activator Inhibitor-1 (PAI-1) could be involved in MDD. For example, PAI-1 is found in brain structures related to mood regulation (e.g. amygdala, hippocampus, pre- frontal cortex) and in blood circulation [6, 22, 30, 36, 45]. ...
The link between the production of PAI-1 inducers such as tumor necrosis factor-alpha and transforming growth factor-beta and the production of PAI-1 by adipose tissue was also evaluated. Blood samples were obtained as soon as possible to the induction of anesthesia from 30 patients undergoing ...
An abundant literature suggests that the Plasminogen Activator Inhibitor-1 (PAI-1) could be involved in MDD. For example, PAI-1 is found in brain structures related to mood regulation (e.g. amygdala, hippocampus, pre- frontal cortex) and in blood circulation [6, 22, 30, 36, 45]. ...
关键词:基因多念性;冠心病;抑郁发作;纤维蛋白褡解酶原激活物抑制剂一1 第l页 ABSTRACT 【ob.iect“e】 1.Toidemify the relationship ofPAI一1 gene 4G/5G polymo叩hism and depressiVe disorder. 2.Tbidentify tIle relationship ofPAI—l gene4G/5G ...
We found no correlation between demographic and surgical parameters and the plasma concentrations of PAI-1 and t-PA/PAI-1 complex. However, preoperative PAI-1 levels correlated inversely with 24 hour postoperative blood loss (Figure 3; r = − 0.3, P = 0.009). In contrast, the correlation ...
1.在我国天津及河北省地区汉族人群中存在PAI-14G/5G基因多态性。 2.PAI-14G/5G基因多态性与GDM发病相关,4G/4G基因可能为我国天 津及河北省地区汉族人群GDM的易感基因。 3.GDM患者中4G/4G基因携带者比5G/5G基因型患者取更明显,可用 于指导GDM的防治及预测疾病严重程度。 4.GDM患者与糖耐量正常孕妇相比,更...