PAI-1, kidney, EMT, angiotensin, aldosterone, thymosin β-4, ReviewSubstantial evidence demonstrates a link of increased plasminogen activator inhibitor-1 (PAI-1) and glomerulosclerosis and kidney fibrosis, providing a novel therapeutic option for prevention and treatment of chronic kidney diseases. ...
The elusive monomeric metaphosphate anion is generated rapidly at room temperature by the fragmentation of threo- or erythro- (1,2-dibromo-1-phenylpropyl)phosphonate in the presence of a hindered base; it reacts at the carbonyl groups of... AC Satterthwait,FH Westheimer - 《Journal of the Am...
Studies have shown PAI-1 to be also involved in fibrosis. 包装清单: 产品编号 产品名称 包装 AF7965 PAI-1/SERPINE1 Rabbit Polyclonal Antibody 50μl AZ050 Western一抗稀释液 50ml — 说明书 1份 保存条件: PAI-1/SERPINE1 Rabbit Polyclonal Antibody -20ºC保存,Western一抗稀释液-20º...
特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)是一种原因不明的慢性,进行性间质性疾病.起病引袭,自然病程持续进展,临床上以进行性呼吸困难和低氧血症为主要特征.IPF的基础病因目前还不清楚,以往的研究多认为与多种细胞因子如:转化生长因子-β(TGF-β),肿瘤坏死因子-α(TNF-α),血小板源性生长因子(PDGF)...
METHODS:Liverfibrosiswasinducedinrats byintraperitonealinjectionofDMN.Allrats weresacrificedtotakelivertissuespecimens. Formalin-fixedliversectionswerestainedwith hematoxylinandeosin(HE)andSiriusRedto evaluategeneralhistologyandhepaticfibrosis, respectively.TheexpressionofOPNandPAI-1 ...
Serpin E1, also known as Plasminogen Activator Inhibitor-1 (PAI-1), is the primary inhibitor of urokinase-type and tissue-type plasminogen activators (uPA and tPA) which convert Plasminogen to Plasmin. The PA-Plasmin system is involved in fibrinolysis, tissue fibrosis, angiogenesis, wound healing...
Substantial evidence demonstrates a link of increased plasminogen activator inhibitor-1 (PAI-1) and glomerulosclerosis and kidney fibrosis, providing a novel therapeutic option for prevention and treatment of chronic kidney diseases. Several mechanisms contributing to increased PAI-1 will be addressed, incl...
1.Izuhara Y , Takahashi S , Nangaku M , et al. Inhibition of Plasminogen Activator Inhibitor-1 Its Mechanism and Effectiveness on Coagulation and Fibrosis[J]. Arteriosclerosis Thrombosis and Vascular Biology, 2008, 28(4):672-677.2.Izuhara Y , Yamaoka N , Kodama H , et al. A novel in...
氯沙坦对肝纤维化鼠TIMP-1, PAI-1表达的影响. 世界华人消化杂志 2004; 12(6): 1361-1364 Effects of losartan on TIMP-1 and PAI-1 expression in rat hepatic fibrosis Yan-Ni Meng, Gui-Ying Zhang, Qian Li Yan-Ni Meng, Gui-Ying Zhang, Qian Li, Department of Gastroenterology, Xiangya ...