The early initiation and continuation of antifibrinolytic agents, Epsilon-aminocaproic acid or tranexamic acid, during the pregnancy and in the postpartum period, was believed to be successful in preventing major bleeding complications in our patients with complete PAI-1 deficiency. 漏 2013 John Wiley...
结果显示,PAI-1 4G/5G多态性的杂合或纯合遗传都与主要复合结果的风险增加无关。 参考资料: 1、https://www.genecards.org/cgi-bin/carddisp.pl?gene=SERPINE1 2、https://ghr.nlm.nih.gov/condition/complete-plasminogen-activator-inhibitor-1-deficiency#definition 3、《PAI-1和ACE基因多态性与反复自然流产...
E. VERCAUTEREN ET AL: "The hyperfibrinolytic state of mice with combined thrombin-activatable fibrinolysis inhibitor (TAFI) and plasminogen activator inhibitor-1 gene deficiency is critically dependent on TAFI deficiency", JOURNAL OF THROMBOSIS AND HAEMOSTASIS, vol. 10, no. 12, 12 December 2012 (...
Deficiency of plasminogen activator inhibitor-2 impairs nutritionally induced murine adipose tissue development. J. Thromb. Haemost. 5, 2259–2265 (2007). Article CAS PubMed Google Scholar Kawata, Y., Mimuro, J., Kaneko, M., Shimada, K. & Sakata, Y. Expression of plasminogen activator ...
目的研究PAI-1基因启动区4G/5G多态性在中国北方汉族人2型糖尿病(DM)患者及并发脑梗死(CI)患者中的分布,以及各组中血浆PAI—1抗原水平的变化.方法将280名受试对象分为4组:健康对照组(92例),非DM脑梗死组(60例),单纯DM组(88例)及DM并发CI组(40例).全部受试对象均需应用EI.ISA法测定血浆PAI—1抗原水平,...
Plasminogenactivatorinhibitor-1 and type2diabetes: a systematic review and meta-analysis of observational studies. Deficiency ofplasminogenactivatorinhibitor2in plasma of patients with hereditary angioedema with normal C1inhibitorlevels. Selectiveinhibitionof brain endothelial Rho-kinase-2provides optimal protectio...
Menopause accelerates bone loss due to estrogen deficiency and age-related linear bone loss. We investigated plasminogen activator inhibitor-1 (PAI-1) gene polymorphisms in postmenopausal women with osteoporotic vertebral compression fractures (OVCFs). In this case-control study, 355 postmenopausal women...
Pathological Role PAI-1 Role in Cardiovascular Disease In humans, PAI-1 deficiency is a rare disorder that is attributed to mutations in the SERPINE1 gene that leads to either the absence of PAI-1 plasma detectable levels or the production of a non-functional PAI-1 protein [151–153]. ...
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PAI-1deficiencypregnancyComplete plasminogen activator inhibitor type 1 (PAI-1) deficiency is an exceedingly rare autosomal recessive bleeding disorder previously identified and reported in a large Old Order Amish (OOA) kindred in Indiana [Fay et聽al. Blood 1997; 90: 204]. Mouse models suggest ...