The KEGG p53 signaling pathway entry showing the pathway map and some reference citations.Guocai ChenMichael J. CairelliHalil KilicogluDongwook ShinThomas C. Rindflesch
好在随着技术的发展,其上下游关系正被科学家们梳理的趋于明朗,今天麦子就讲讲其中有着“悠久研究史”的p53信号通路,为啥呢?因为在癌症领域这条通路貌似比其他通路更加重要! 根据KEGG数据库绘制的p53信号通路图。对涉及到癌症的基因突变进行了彩色标示,蓝色:上皮癌;红:白血病或淋巴瘤;紫色:恶性肿瘤;橙色:其他类型的...
LncRNA MEG3调节MDM2通过P53信号通路影响缺血性脑卒中
The genes, the expression level of which increased more than 2-fold after PARP inhibition, are indicated as a black box in the p53 signaling pathway published by the KEGG database. b The mRNA expression profiles shown in (a) were confirmed by RT-PCR. Several genes downstream to Trp53 (...
根据KEGG数据库绘制的p53信号通路图。对涉及到癌症的基因突变进行了彩色标示,蓝色:上皮癌;红:白血病或淋巴瘤;紫色:恶性肿瘤;橙色:其他类型的癌症。(这张图完全属于可收藏级别,记住关键的分子是装逼必备!) 谁是信号通路江湖一把手? p53是一个明星抑癌基因,能调节细胞周期和避免细胞癌变发生,被科学界戏称为“基因组...
EXO1 inhibited P53 signaling in PCa Multigene GO and KEGG enrichment analysis of the pink module, where EXO1 was located, revealed an enrichment of the P53 signaling pathway (Fig. 1H). GSEA results further indicated that EXO1 was a potential pathway to regulate P53 (Fig. 6A). GEPIA results...
综合通过MSigDB、KEGG和GO三个数据库分析mRNA转录组测序结果,氢分子通过上调p53基因的表达,来调节溶酶体-线粒体诱导细胞凋亡 (Fig. 3)。 Fig.3 Hydrogen regulated gene expressions related to the P53-mediated apoptosis signaling pathway. (...
Using univariate regression analysis and the Lasso algorithm applied to the KEGG p53 signaling pathway gene set, 15 significant p53-associated genes were identified. Additionally, the CIBERSORT algorithm was employed to analyze the TIC, uncovering six immune cell types with autonomous prognostic risk ...
KEGG_PATHWAY Beta-alanine metabolism 9 0.7 2.7 Â 10 À 3 0.052 KEGG_PATHWAY Arginine and proline metabolism 15 1.1 2.8 Â 10 À 3 0.05 The p53 signaling pathway and pathways related to the control of the cell cycle are deregulated, as expected (analysis carried out including all ...
KEGG term “P53 signaling pathway” in STAT6 low expression group.EHBE cells were transfected with indicated plasmid and harvested for immunoprecipitation and immunoblot analysis with the indicated antibodies.FThe protein lysis of lung tissue from WT and STAT6cKOmice were subjected to ...