The p53-signaling pathway and colorectal cancer: Interactions between downstream p53 target genes and miRNAsColorectal CancerTP53miRNAmRNACRCcolorectal cancerFDRfalse discovery rateFCfold changeKPNCKaiser Permanente of Northern CaliforniaKEGGKyoto Encyclopedia of Genes and GenomicsHRHazard RatiomiRNAmicroRNAMSI...
综合通过MSigDB、KEGG和GO三个数据库分析mRNA转录组测序结果,氢分子通过上调p53基因的表达,来调节溶酶体-线粒体诱导细胞凋亡 (Fig. 3)。 Fig.3 Hydrogen regulated gene expressions related to the P53-mediated apoptosis signaling pathway. (...
The genes, the expression level of which increased more than 2-fold after PARP inhibition, are indicated as a black box in the p53 signaling pathway published by the KEGG database. b The mRNA expression profiles shown in (a) were confirmed by RT-PCR. Several genes downstream to Trp53 (...
The KEGG pathway analysis of the 411 DEGs revealed that the genes were significantly enriched in the pathways of DNA replication, p53 signaling pathway, cell cycle, ECM-receptor interaction, Arrhythmogenic right ventricular cardiomyopathy, leukocyte trans-endothelial migration, lipid and atherosclerosis and...
KEGG pathway enrichment analysis showed that SIRT4 was involved in regulating the AMPK signaling pathway, p53 signaling pathway, and cell cycle (Fig. 3A). Combined with the proteomics and metabolomics analysis, we found that SIRT4 was involved in regulating the activation of the p53, AMPK, and...
Data were aligned to the human hg38 built (UCSC) and analysed with the Dr.Tom data visualisation solution (BGI) that includes gene set enrichment analysis (GSEA) for gene ontology and KEGG pathways (FDR < 0.05). Histology Immunohistochemical stainings of formalin-fixed, paraffin embedded ...
LncRNA MEG3调节MDM2通过P53信号通路影响缺血性脑卒中
KEGG term “P53 signaling pathway” in STAT6 low expression group.EHBE cells were transfected with indicated plasmid and harvested for immunoprecipitation and immunoblot analysis with the indicated antibodies.FThe protein lysis of lung tissue from WT and STAT6cKOmice were subjected to ...
羧基末端乙酰化修饰调控抑癌蛋白p53转录特异性
KEGG_PATHWAY Beta-alanine metabolism 9 0.7 2.7 Â 10 À 3 0.052 KEGG_PATHWAY Arginine and proline metabolism 15 1.1 2.8 Â 10 À 3 0.05 The p53 signaling pathway and pathways related to the control of the cell cycle are deregulated, as expected (analysis carried out including all ...