Results: A p53 response element binding sequence is present in HBV genome at upstream of enhancer I from 1047 to 1059 hp. This sequence is capable of binding to p53 protein and increasing accumulation of p53 protein in cells. Conclusion: The results strongly suggest that DNA-protein binding of...
(also known as NOXA); PR, proline-rich domain; PRIMA-1, p53 reactivation and induction of massive apoptosis; RB, retinoblastoma; RE, response element; Reg, carboxy-terminal regulatory domain; RITA, reactivation of p53 and induction of tumour cell apoptosis; rNTP, ribonucleotide triphosphate; SFN...
价格￥5580 包装100 ug 最小起订量100 ug 发货地湖北 更新日期2024-12-08 产品详情 中文名称:P53抗体(小鼠单抗)产品类别:抗体 背景资料 p53, a 53 kDa protein, binds to a DNA consensus sequence, the p53 response element, and regulates normal cell cycle events by activating transcription of genes in...
p53 response element A short sequence of DNA in or near a gene that can bind p53, which then regulates the transcriptional activity of that gene. p53 family This family includes p53, p63 and p73, which have a significant degree of sequence homology particularly in the sequence-specific DNA-bi...
HPV-18 E6 inhibits p53 DNA binding activity regardless of the oligomeric state of p53 or the exact p53 recognition sequence Oncogene, 13 (1996), pp. 471-480 View in ScopusGoogle Scholar Wang et al., 2009 B. Wang, Z. Xiao, E.C. Ren Redefining the p53 response element Proc. Natl. Aca...
p53-mediated activation of transcription is largely dependent on sequence-specific DNA binding. The consensus p53-binding motif consists of two half-sites separated by 0–13 nucleotides (18, 23). Each half-site consists of the sequence RRRC(A/T)(T/A)GYYY. p53 binds the response element as...
Sequence-specifictranscriptionfactor(bothanactivatorandarepressor) TP53geneislocatedontheshortarmofchromosome17(17p13.1)p53proteinstructure AD1:activationdomain1AD2:activationdomain2PRD:prolinerichdomainHCDI:HighlyConservedDomainI Tetra(4D):oligomerizationdomainNEG:negativeregulationdomainNES:nuclear...
Thus, P1 is a positive p53-response element. In contrast, deletion of P2 enhances P1-induced activation. P2 represses transcription when substituted for P1 or when relocated midway between P1 and P2. P2-mediated repression is sequence-dependent, because it is reversed to activation when P2 is ...
[11,12,13], p53 homologs from multiple species have been shown to contain a conserved DNA binding domain that can specifically trans-activate a common binding motif: the p53 response element (p53RE) [14]. Yet, gene regulation has been reported to differ for at least some of its targets....
The p53 tumor suppressor binds target genes through p53 response elements (REs) that comprise two decameric half-sites with the consensus sequence RRRCWWGYYY, separated by a spacer of 0–13 bp. In addition, results from multiple studies suggest that p53 can bind and transactivate target genes...