Microglia are specialized resident myeloid cells that mediate CNS innate immune responses. Disease-relevant stimuli, such as reactive oxygen species (ROS), can influence microglia activation. Previously, we observed that p53, a ROS-responsive transcription factor, modulates microglia behaviors in vitro ...
Microglia maintain CNS homeostasis through pathogen containment, phagocytosis of debris, and initiation of tissue-repair cascades. However, an unregulated pro-inflammatory response can lead to tissue injury and dysfunction in both acute and chronic inflammatory states. Therefore, regulation of the molecular...
Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death. Nat Chem Biol. 2020;16:278. Article CAS PubMed PubMed Central Google Scholar Dai EY, Meng LJ, Kang R, Wang XF, Tang DL. ESCRT-III-dependent membrane repair blocks ferroptosis. Biochemical ...
Glioblastoma cell-derived lncRNA-containing exosomes induce microglia to produce complement C5, promoting chemotherapy resistance. Cancer Immunol Res. 2021;9:1383–99. Article CAS PubMed Google Scholar Arun G, Diermeier S, Akerman M, Chang KC, Wilkinson JE, Hearn S, et al. Differentiation of ...
We predicted interactions using MultiNicheNet [35] by determining genes differentially expressed between AD and control in all cell types before filtering for our sender (astrocytes, microglia, oligodendrocytes, and OPCs) and receiver (excitatory and inhibitory neurons) cells of interest (Fig.1B). ...
The role of microglia and matrix metalloproteinases involvement in neuroinflflammation and gliomas[J]. Clin Dev Immunol, 2013,2013:914104. doi: 10.1155/2013/914104 . 返回引文位置Google Scholar 百度学术 万方数据 [2] Sato H , Takino T . Coordinate action of membrane-type matrix metalloproteinase...
Role of microglia in plaque formation in senile dementia of the Alzheimer type. An immunohistochemical study. Virchows Arch B Cell Pathol Incl Mol Pathol. 1986;51(3):247–54. 19. Rogers J, Luber-Narod J, Styren SD, Civin WH. Expression of immune system-associated antigens by cells of ...
Microglia are resident immune cells in the central nervous system that become activated and produce pro-inflammatory and neurotrophic factors upon activati... M Tsuda,E Toyomitsu,M Kometani,... - 《Journal of Cellular & Molecular Medicine》 被引量: 71发表: 2010年 Cooperative interaction between ...
Relative role of Akt, ERK and CREB in alcohol-induced microglia P2X4R receptor expression. Alcohol alcohol 2016; 51: 647–654. 8. Muller PA, Caswell PT, Doyle B, Iwanicki MP, Tan EH, Karim S et al. Mutant p53 drives invasion by promoting integrin recycling. Cell 2009; 139: 1327–...
Taurine reduces microglia activation in the brain of aged senescence-accelerated mice by increasing the level of TREM2 2024, Scientific Reports Metabolomics assisted by transcriptomics analysis to reveal metabolic characteristics and potential biomarkers associated with treatment response of neoadjuvant therapy ...