[22] Li D,Marchenko ND,Schulz R,et al. Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells[J]. Mol Cancer Res,2011,9(5):577-588. [23] Li D,Marchenko ND,Moll UM. SAHA shows preferential cytotoxicity in mutant p...
Aberrant p53 immunoreactivity has been found in skin premalignancies and dysplasias such as Bowen's disease and actinic keratoses. Vulval lichen sclerosus (LS) has been reported to be pre-malignant, with an association of vulval carcinoma in 3% to 6% of patients. In contrast, non-genital LS...
14. Tovar C, Rosinski J, Filipovic Z, et al. Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy.Proc Natl Acad Sci U S A. 2006;103(6):1888-1893. doi:10.1073/pnas.0507493103 15. Skalniak L, Kocik J, Polak J, et al. Prolonged Idasanutlin...
et al. Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for the...
Tovar C, Rosinski J, Filipovic Z, et al. Small-molecule MDM2 antagonists reveal aberrant p53 sig...
The ARF tumor suppressor initiates the cellular response to aberrant oncogene activation through binding to and inhibiting the activity of Hdm2/Mdm2, the inhibitor of p53. However, many pathways also active in the cell will oppose p53 function if left unchecked. An example of this, is the RelA...
Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. Proc. Natl Acad. Sci. USA 103, 1888–1893 (2006). Article CAS PubMed PubMed Central Google Scholar Kucab, J. E., Hollstein, M., Arlt, V. M. & Phillips, D. H. Nutlin-3a selects for...
Aberrant signature patterns of ATM, γ-H2AX and p53 proteins in the patients exposed to methyl isocyanate diagnosed with gallbladder cancer.Aberrant signature patterns of ATM, γ-H2AX and p53 proteins in the patients exposed to methyl isocyanate diagnosed with gallbladder cancer.ATMp53...
The phosphorylation of p53 on S15, T18, and S20 residues disrupts the binding of p53-MDM2, leading to aberrant p53 regulation and aging phenotypes [31, 32]. In addition, MDM4 has been shown to interact with MDM2 to reverse MDM2-mediated p53 degradation while maintain suppression of p53 ...
p53 Aphosphoproteinmadeof393aminoacidsGotitsnameduetoitsmolecularmassasitis53kilodalton Sequence-specifictranscriptionfactor(bothanactivatorandarepressor) TP53geneislocatedontheshortarmofchromosome17(17p13.1)p53proteinstructure AD1:activationdomain1AD2:activationdomain2PRD:prolinerichdomainHCDI...