Aberrant nuclear p53 protein expression detected by immunohistochemistry is associated with hemizygous P53 deletion and poor survival for multiple myeloma. H Chang,J Yeung,C Qi,W Xu. British Journal of Haematology . 2007Chang H; Yeung J; Qi C;.Aberrant nuclear p53 protein expression detected by ...
[22] Li D,Marchenko ND,Schulz R,et al. Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells[J]. Mol Cancer Res,2011,9(5):577-588. [23] Li D,Marchenko ND,Moll UM. SAHA shows preferential cytotoxicity in mutant p...
[22] Li D,Marchenko ND,Schulz R,et al. Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells[J]. Mol Cancer Res,2011,9(5):577-588. [23] Li D,Marchenko ND,Moll UM. SAHA shows preferential cytotoxicity in mutant p...
14. Tovar C, Rosinski J, Filipovic Z, et al. Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy.Proc Natl Acad Sci U S A. 2006;103(6):1888-1893. doi:10.1073/pnas.0507493103 15. Skalniak L, Kocik J, Polak J, et al. Prolonged Idasanutlin...
14. Tovar C, Rosinski J, Filipovic Z, et al. Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy.Proc Natl Acad Sci U S A. 2006;103(6):1888-1893. doi:10.1073/pnas.0507493103 15. Skalniak L, Kocik J, Polak J, et al. Prolonged Idasanutlin...
25 Moreover, large number of aberrant Hox gene expression have been found in various cancers.26 Next, we asked whether any of Hox genes were influenced by TUG1, thus participating in tumor progression. qRT-PCR analysis was performed to detect the expression of HOX genes. The results showed ...
Consequently, LAMTOR1-depleted cells face an aberrant lysosomal catabolism that produces excessive reactive oxygen species (ROS). ROS accumulation in turn triggers p53-dependent cell cycle arrest and apoptosis. Both mTORC1 activity and the stimulated autophagy are not necessary to this lysosomal cell ...
An aberrant cell cycle impairs DNA re... H Shen,Y Zheng,EM Sturgis,... - 《Cancer Letters》 被引量: 207发表: 2002年 Relationship between p53 codon 72 polymorphism and susceptibility to sunburn and skin cancer. Upregulation of p53 protein induces either growth arrest or apoptosis in response...
Aberrant metabolism in hexosamine biosynthetic pathway (HBP) has been observed in several cancers, affecting cellular signaling and tumor progression. However, the role of O-GlcNAcylation, a post-translational modification through HBP flux, in apoptosis remains unclear. Here, we found that hyper-O-...
Thus, combined inactivation of Rb and p21Waf1/Cip1 augments endoreduplication and apoptosis, whereas E2F1 and p53 are dispensable during aberrant myogenesis in Rb-deficient fetuses. 展开 关键词: Rb p21 E2F1 p53 cell cycle apoptosis endoreduplication myogenesis ...