评论次数: 0 文档热度: 文档分类: 汽车/机械/制造--机械理论及资料 文档标签: P450药物相互作用作用作用药物相互药物作用 系统标签: 药物相互作用rifampinglyburidenaphthoflavotolbutamide P450DrugInteractionTablehttp://medicine.iupui.edu/clinpharm/DDIs/table.aspxSUBSTRATES1A22B62C82C92C192D62E13A4,5,7amitriptyli...
thermophiles CYP116B46 还原酶 大鼠 CPR 表 2 RPs 融合构建实例 Table 2 Fusion construction examples of RPs P450 酶 Enzyme P450 哺乳动物肝脏 CYPs A. Oryzae CYP57B3 Jeotgalicoccus P450 OleTJE B. megaterium P450 BM3 血 红素域 S. venezuelae P450 PikC Streptomyces P450 TamI A. orientalis P450...
druginfo@ /Drugs/GuidanceComplianceRegulatoryInformation/Guidances/default.htm U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) January 2020 Clinical Pharmacology Contains Nonbinding Recommendations TABLE OF CONTENTS I. INTRODUCTION 1 ...
only a small number of these are involved in drug metabolism. 2,3 The CYP isoforms of interest in drug metabolism are CYP3A4, CYP2D6, CYP1A2, CYP2C9 and CYP2C19. This information can be found in most pharmaceutical references, such as the detailed and regularly updated table available fro...
Biopharm Drug Dispos 35:543-552.Lu C, Suri A, Shyu WC, Prakash S (2014) Assessment of cytochrome P450-mediated drug-drug interaction potential of orteronel and exposure changes in patients with renal impairment using physiologically based pharmacokinetic modeling and simulation. Biopharm Drug Dispos...
1 for the imidazole drug tioconazole with WT and DM heme domains. The binding affinities for the WT and DM heme domains are 18.4 ± 0.9 μM and 0.39 ± 0.03 μM, respectively. Table 1 shows the collated data sets for the binding of the 17 different azoles to WT and DM...
Therefore, it is not surprising then that the wild-type and F153L mutant exhibit similar affinity for the 4-PI ligand (Table 2). It is worth noting that a van der Waals interaction between Phe-153 and Phe-162, two residues that are 4.2 Å apart and rotated 90° with respect to ...
All drug and target nomenclature follow Alexander (Table 1). By comparing the simultaneous mixed and sequential fits to the total dataset, we found that the description of the data by the sequential analysis approach was significantly worse, as indicated by a difference in the MVOF of 297 ...
The HLM (0.1 mg/ml) or recombinant enzyme (0.05 mg/ml) along with the probe substrate of each respective enzyme (Table 1) was warned in phosphate buffer (pH 7.4) containing MgCl2 (3 mM) at 37 °C for 5 min. Functional activity reactions were initiated with the addition of NADPH (1 ...
TABLE 1. Oligomerization of CYP3A4, CYP3A4, and CYP2E1 in model microsomes studied by LRET The values given in the table were obtained by fitting of the titration curves with the Hill equation (in the case of the interactions of 3A enzymes) or with the equation for the equilibrium of ...