Guengerich FP (2014) Cytochrome P450-mediated drug interactions and cardiovascular toxicity: the Seldane to Allegra transformation. In: Wang J, Urban L (eds) Predictive ADMET: integrated approaches in drug discovery and development. Wiley, New York, Chap. 23, pp 523–534...
In vitro studies demonstrated that iberdomide predominantly undergoes oxidative metabolism mediated by cytochrome P450 (CYP) 3A4/5 but had no notable inhibition or induction of CYP enzymes. Consequently, the potential of iberdomide as a victim of drug-drug interactions (DDI) was evaluated in a ...
We predicted the drug-drug interaction (DDI) potential of siponimod in presence of cytochrome P450 (CYP)2C9/CYP3A4 inhibitors/inducers in subjects with different CYP2C9 genotypes by physiologically-based pharmacokinetic (PK) modeling. The model was established using in vitro and clinical PK data...
摘要: Kelly L. Cozza, Sott C. Armstrong, and Jessica R. Oesterheld's second edition of the Concise Guide to Drug Interaction Principles of Medical Practice: Cytochrome P450s, UGTs, P-Glycoproteins is reviewed.DOI: 10.1097/01.chi.0000157544.74509.06 年份: 2005 ...
Hisaka A,Ohno Y,Yamamoto T,et al.Prediction of pharmacokinetic drug-drug interaction caused by changes in cytochrome P450activity using in vivo information.Pharmacology and Therapeutics. 2010Hisaka A,Ohno Y,Yamamoto T,et al.Prediction of pharmacokinetic drug-drug interaction caused by changes in ...
The perpetrator effect of the investigational drugs on cytochrome P450 3A (CYP3A) was assessed by analyzing both midazolam and 1‐OHM in plasma and evaluating their pharmacokinetic parameters. Given the almost exclusive metabolism of the parent drug by CYP3A to the main metabolite 1‐OHM, ...
Cytochrome P450 inhibitory potential of selected Indian spices-possible food drug interaction. Food Res. Int. 45, 69-74.S. Pandit, P.K. Mukherjee, K. Mukherjee, et al. "Cytochrome P450 inhibitory potential of selected Indian spices--possible food drug interaction," Food research international, ...
C. (2014). Cytochrome P450s: mechanisms and biological implications in drug metabolism and its interaction with oxidative stress. Curr. Drug Metab. 15, 719-742. doi: 10.2174/1389200215666141125121659Bhattacharyya S, Sinha K, Sil PC (2014) Cytochrome P450s: Mechanisms and biological implications in...
Drug‐Drug Interaction Study to Assess the Effect of Cytochrome P450 Inhibition and Induction on the Pharmacokinetics of the Novel Cereblon Modulator Avadomide (CC‐122) in Healthy Adult SubjectsavadomideCYP1A2CYP3Adrug‐drug interactionsimmunomodulatory drug...
Drug-drug interactionIberdomideCC-220Clinical pharmacologyPurpose Iberdomide is a cereblon E3 ligase modulator capable of redirecting the protein degradation machinery of the cell towards the elimination of target proteins potentially driving therapeutic effects. In vitro studies demonstrated that iberdomide...