P4-ATPases被称为翻转酶,这种酶通过水解ATP将细胞膜中的脂质从胞外侧转移到胞质侧,是创造和维持细胞膜脂质不对称分布的关键因素。细胞膜成分的不对称分布对细胞的多种功能至关重要。下列叙述错误的是 A. 细胞膜上蛋白质的分布也是不对称的 B. 翻转酶发挥作用可使磷脂分子头部在膜内,尾部在膜外 C. 细胞膜磷脂...
P4型ATP酶(P4-ATPase)是脂质翻转酶(lipid flippase),负责将脂质从真核细胞膜的胞外侧小叶(细胞外侧或细胞器的囊腔侧)主动转运到细胞质小叶,帮助维持生物膜的脂质不对称性分布,在囊泡运输等细胞通路中发挥重要作用。P4-ATPase突变或表达异常被...
P4 ATPase isoforms are redundant to some extent, but structural defects of certain isoforms can still lead to rather severe pathologies at the whole-organism level due to tissue specificity of expression of the corresponding genes and variability of the intracellular localization of the proteins and ...
77,78, little is known about the role of P4 ATPases in mycotoxin detoxification, even though ALA4 was demonstrated to be involved in heavy mental detoxification79. In this study, using theFusariumtoxin DON andVerticilliumtoxin CIA as probes, we identified twoArabidopsisP4 ATPase genes,AtALA1and...
P4-ATPases被称为翻转酶,这种酶通过水解ATP将细胞膜中的脂质从胞外侧转移到胞质侧,是创造和维持细胞膜脂质不对称分布的关键因素。细胞膜成分的不对称分布对细胞的多种功能至关重-e卷通组卷网
ATP2, the essential P4-ATPase of malaria parasites, catalyzes lipid-dependent ATP hydrolysis in complex with a Cdc50 β-subunitGene targeting approaches have recently demonstrated the essential role for the malaria parasite of membrane transport proteins involved in lipid transport and in the ...
目前尚不清楚.另外,课题组在杀虫真菌球孢白僵菌中鉴定到一个P4-ATPase(BbCrpa),它能通过囊泡运输的方式将具有抗真菌活性的Cs A和FK506运送到液泡,实现细胞解毒.黄萎病菌产生的毒素被认为是其重要的致病因子.能否在棉花中表达真菌的这类P4-ATPase基因,通过细胞解毒的方式提高植物黄萎病的抗性?围绕这些问题,本文展开...
The causative mutations were ascribed to Atp11c, which encodes a P4-type ATPase with no previously described function. Our data establish an essential, cell-autonomous and context-sensitive function for ATP11C, a putative aminophospholipid flippase, in B cell development. This is a preview of ...
神经干细胞具有自我更新的能力,通过非对称分裂的方式生成神经元,星形胶质细胞,少突胶质细胞等,组成神经组织,对神经退行性疾病的治疗,神经损伤修复和神经再生与功能重建具有潜在的应用价值.神经干细胞分化涉及复杂的信号途径,在这个过程中,细胞内多条信号转导通路的关键分子-Rho-GTP酶通过与其下游效应元件的作用调节神经细...
27. CDC50 proteins consist of two transmembrane segments joined by a highly glycosylated exocytoplasmic segment. Interaction of CDC50 with the α-subunit is essential for the proper folding, transport activity, and exit of the P4-ATPase complexes from the endoplasmic reticulum12,25,26,28,29,30,...