非ST段抬高型ACS患者PCI术前进行的P2Y12受体抑制剂预处理是否有益? “In the DUBIUS (Downstream Versus Upstream Strategy for the Administration of P2Y12 Receptor Blockers in Non-ST Elevated Acute Coronary Syndromes With Initia...
Interestingly, in contrast to THP-1 monocytes, THP-1 monocytes, after differentiation to macrophages, directly expressed the P2Y12receptor and consequently ADP was found to be a potent chemoattractant. Again, P2Y12receptor blockers antagonised this effect. Accordingly, stimulation of THP-1 macrophages...
IntroductionFollowing ACS or PCI, P2Y12 receptor blockers such as clopidogrel or prasugrel are standardly prescribed alongside aspirin as dual anti-platelet therapy in a "one size fits all" approach, however recurrent thrombotic events occur. Despite the logical hypothesis that thrombotic risk should ...
1. P2Y12receptor blockers include: Clopidogrel, Ticlopidine, Ticagrelor, Prasugrel and Cangrelor. 2. GPIIb-IIIa inhibitors [Abciximab, Eptifibatide and Tirofiban] - may affect the results of the VerifyNow P2Y12 assay system if administered with 48hrs of sample collection. ...
For patients with an aspirin allergy or intolerance, antagonists of the platelet P2Y12 receptor are an alternative. For patients undergoing percutaneous coronary intervention (PCI) dual antiplatelet therapy (DAPT: aspirin combined with a P2Y12 blocker) has become the standard of care [2]. In ...
The normal value (without P2Y12 receptor blockers) of the platelet reactivity index is 69% to 100% (12). Platelet reactivity index values of >42% were most sensitive to predict ischemic events 64, 67, 68 (Table 2). A positive VASP test result corresponded to an OR of 1.04 to 11.18 ...
COX x P2Y12 receptor 作用机制 COX抑制剂[+1] 在研机构 Torrent Pharmaceuticals Ltd. 原研机构 Torrent Pharmaceuticals Ltd. 在研适应症 急性冠状动脉综合征 非在研适应症- 最高研发阶段批准上市 首次获批国家/地区 印度 首次获批日期2016-01-01 1,670 ...
P2Y12 receptor blockers are anti-inflammatory drugs inhibiting both circulating monocytes and macrophages including THP-1 cells Sci. Rep., 11 (1) (2021), p. 17459 View in ScopusGoogle Scholar [80] L. Kloss, C. Dollt, K. Schledzewski, A. Krewer, S. Melchers, C. Manta, C. Sticht...
One of the key agonists responsible for platelet activation, sustained expression of the activated glycoprotein (GP) IIb/IIIa receptor, resultant amplification of platelet aggregation, and thrombus stabilization is adenosine diphosphate (ADP). The surface of the activated platelet is an important site ...
p-PI3K and p-AKT by western blot analysis. The above signaling proteins were also detected in human-derived megakaryocyte cell strains (Meg-01) treated with different concentration of adenosine diphosphate (ADP). CFTRinh-172, ...